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Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/24799

Title: Executive ‘brake failure’ following deactivation of human frontal lobe
Author: GARAVAN, HUGH PATRICK
Author's Homepage: http://people.tcd.ie/garavanh
Keywords: Psychology
Issue Date: 2006
Publisher: MIT Press
Citation: Chambers, C. D., Bellgrove, M. A., Stokes, M. G., Henderson, T. R., Garavan, H., Robertson, I. H., & Mattingley, J. B. ‘Executive ‘brake failure’ following deactivation of human frontal lobe’ in Journal of Cognitive Neuroscience, 18, (3), 2006, pp 444 - 455
Series/Report no.: Journal of Cognitive Neuroscience
18
3
Abstract: In the course of daily living, humans frequently encounter situations in which a motor activity, once initiated, becomes unnecessary or inappropriate. Under such circumstances, the ability to inhibit motor responses can be of vital importance. Although the nature of response inhibition has been studied in psychology for several decades, its neural basis remains unclear. Using transcranial magnetic stimulation, we found that temporary deactivation of the pars opercularis in the right inferior frontal gyrus selectively impairs the ability to stop an initiated action. Critically, deactivation of the same region did not affect the ability to execute responses, nor did it inf luence physiological arousal. These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition.
Description: PUBLISHED
URI: http://hdl.handle.net/2262/24799
Appears in Collections:Psychology (Scholarly Publications)

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