Murphy, P., Topilko, P., Schneider-Maunoury, Seitanidou, T. and Charnay, P. ‘The regulation of Krox-20 expression reveals important steps in the control of peripheral glial cell development’ in Development, 122, (9), 1996, pp 2847 - 2857
Development 122 9
The zinc finger transcription factor gene Krox-20 is
expressed in Schwann cells and is required for the myelination
of peripheral nerves. We show that the regulation
of Krox-20 expression in peripheral glial cells reveals three
important steps in the development and differentiation of
these cells. (i) Expression of Krox-20 in Schwann cells
requires continuous neuronal signalling via direct axonal
contact. Therefore Krox-20 appears to be a key component
of the transduction cascade linking axonal signalling to
myelination. (ii) Krox-20 inducibility is acquired by
Schwann cells at the time that they are formed from their
precursors. Diffusible factor(s) synthesised by the neural
tube can mediate this transition and can be mimicked by
NDFb or a combination of CNTF and bFGF. Furthermore,
the neural tube activity is blocked by a hybrid protein containing
the NDF-binding domain of the ErbB4 receptor,
strongly implicating NDF in the physiological transition.
(iii) In sensory ganglia, the microenvironment is capable of
negatively regulating Krox-20, presumably by preventing
the conversion of satellite glial cells toward a Schwann celllike
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