The University of Dublin | Trinity College -- Ollscoil Átha Cliath | Coláiste na Tríonóide
Trinity's Access to Research Archive
Home :: Log In :: Submit :: Alerts ::

TARA >
School of Psychology >
Psychology >
Psychology (Scholarly Publications) >

Please use this identifier to cite or link to this item: http://hdl.handle.net/2262/15318

Title: Dissociation in response to methylphenidate on response variability in a group of medication naïve children with ADHD
Author: GILL, MICHAEL
FITZGERALD, MICHAEL
JOHNSON, KATHERINE ANNE
ROBERTSON, IAN H
Author's Homepage: http://people.tcd.ie/johnsoka
http://people.tcd.ie/mgill
http://people.tcd.ie/mifitzge
http://people.tcd.ie/iroberts
Keywords: Response time
Methylphenidate
Attention Deficit Hyperactivity Disorder
ADHD
Variability
Dopamine
Issue Date: 2008
Citation: Johnson, K.A., Barry, E., Bellgrove, M.A., Cox, M., Kelly, S.P., Daibhis, A., Daly, M., Keavey, M., Watchorn, M., Fitzgerald, M., McNicholas, F., Kirley, A., Robertson, I.H., Gill, M, Dissociation in response to methylphenidate on response variability in a group of medication naïve children with ADHD, Neuropsychologia, 46, 5, 2008, 1532 - 1541
Series/Report no.: Neuropsychologia
46
5
Abstract: Increased variability in reaction time (RT) has been proposed as a cardinal feature of attention deficit hyperactivity disorder (ADHD). Increased variability during sustained attention tasks may reflect inefficient fronto-striatal and fronto-parietal circuitry; activity within these circuits is modulated by the catecholamines. A disruption to dopamine signaling is suggested in ADHD that may be ameliorated by methylphenidate (MPH). This study investigated the effects of MPH administration on the variability in RT and error performance on a sustained attention task of a group of 31 medication naïve children with ADHD, compared with 22 non-ADHD, non-medicated, control children. All children performed the fixed-sequence sustained attention to response task (SART) at two time-points: at baseline and after six weeks. The children with ADHD were tested when medication naive at baseline and after six weeks of treatment with MPH and whilst on medication. The medication naïve children with ADHD performed the SART with greater errors of commission and omission when compared with the control group. They demonstrated greater standard deviation of RT and fast moment-to-moment variability. They did not differ significantly from the control group in terms of slow variability in RT. MPH administration resulted in reduced and normalised levels of commission errors and fast, moment-to-moment variability in RT. MPH did not affect the rate of omission errors, standard deviation of RT or slow frequency variability in RT. MPH administration may have a specific effect on those performance components that reflect sustained attention and top–down control rather than arousal.
Description: PUBLISHED
PMID 18289615
URI: http://dx.doi.org/doi:10.1016/j.neuropsychologia.2008.01.002
http://hdl.handle.net/2262/15318
Related links: http://dx.doi.org/10.1186/1471-244X-10-67
Appears in Collections:Psychology (Scholarly Publications)

Files in This Item:

File Description SizeFormat
070809-KJ MTH FSART_Neuropsychologia_accepted.docpostprint819 kBMicrosoft WordView/Open


This item is protected by original copyright


Please note: There is a known bug in some browsers that causes an error when a user tries to view large pdf file within the browser window. If you receive the message "The file is damaged and could not be repaired", please try one of the solutions linked below based on the browser you are using.

Items in TARA are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback