Browsing by Author "SHARMA, RUCHIKA"
Now showing items 1-2 of 2
- Sort by:
- title
- issue date
- submit date
- Order:
- ascending
- descending
- Results:
- 5
- 10
- 20
- 40
- 60
- 80
- 100
-
Bile acid toxicity structure activity relationships: Correlations between cell viability and lipophilicity in a panel of new and known bile acids using an esophageal cell line (HET-1A)
KELLEHER, DERMOT; SHARMA, RUCHIKA; MAJER, FERENC; WANG, JUN; KEAVENY, RAYMOND; LONG, AIDEEN; GILMER, JOHN (2010)The molecular mechanisms and interactions underlying bile acid cytotoxicity are important to understand for intestinal and hepatic disease treatment and prevention and the design of bile acid-based therapeutics. Bile acid ... -
New fluorescent bile acids: Synthesis, chemical characterization, and disastereoselective uptake by Caco-2 cells of 3-deoxy 3-NBD-amino deoxycholic and ursodeoxycholic acid
LONG, AIDEEN; GILMER, JOHN; EHRHARDT, CARSTEN; WANG, JUN; SALOMON, JOHANNA JESSICA; MAJER, FERENC; KEAVENY, RAYMOND; SHARMA, RUCHIKA (2012)Deoxycholic acid (DCA), a secondary bile acid (BA), and ursodeoxycholic acid (UDCA), a tertiary BA, cause opposing effects in vivo and in cell suspensions. Fluorescent analogues of DCA and UDCA could help investigate ...