Browsing by Author "MOLLOY, ANNE MARIE"
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Biomarkers of folate status in NHANES: a roundtable summary 1-6
MOLLOY, ANNE MARIE (2011)A roundtable to discuss the measurement of folate status biomarkers in NHANES took place in July 2010. NHANES has measured serum folate since 1974 and red blood cell (RBC) folate since 1978 with the use of several different ... -
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary 1 6
MOLLOY, ANNE MARIE (2011)A roundtable to discuss the measurement of vitamin B-12 (cobalamin) status biomarkers in NHANES took place in July 2010. NHANES stopped measuring vitamin B-12?related biomarkers after 2006. The roundtable reviewed 3 ... -
Choline and homocysteine interrelations in umbilical cord and maternal plasma at delivery.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (American Society for Clinical Nutrition, 2005)Background: Little is known about the interactions between choline and folate and homocysteine metabolism during pregnancy despite the facts that pregnancy places considerable stress on maternal folate and choline stores ... -
Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (Oxford University Press, 2006)BACKGROUND: low vitamin B12 concentrations are common in older people, but the clinical relevance of biochemical evidence of vitamin B12 deficiency in the absence of anaemia is uncertain. OBJECTIVE: to examine associations ... -
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2009)Polymorphisms in folate-related genes have emerged as important risk factors in a range of diseases including neural tube defects (NTDs), cancer, and coronary artery disease (CAD). Having previously identified a polymorphism ... -
Confirmation of the R653Q polymorphism of the trifunctional C1-synthase enzyme as a maternal risk for neural tube defects in the Irish population.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (Nature Publishing Group, 2006)The risk of neural tube defects (NTDs) is known to have a significant genetic component that could act through either the NTD patient and/or maternal genotype. The success of folic acid supplementation in NTD prevention ... -
Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (American Association for Clinical Chemistry, 2007)Background: Impaired vitamin B12 function and decreased vitamin B12 status have been associated with neurological and cognitive impairment. Current assays analyze total vitamin B12 concentration, only a small percentage ... -
Determining bioavailability of food folates in a controlled intervention study
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2004)Background: The concept of dietary folate equivalents (DFEs) in the United States recognizes the differences in bioavailability between natural food folates and the synthetic vitamin, folic acid. However, many published ... -
Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2007)Background: Mandatory folic acid fortification of food is effective in reducing neural tube defects and may even reduce stroke-related mortality, but it remains controversial because of concerns about potential adverse ... -
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
MOLLOY, ANNE MARIE (John Wiley, 2008)BACKGROUND?Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folaterelated genes associated with ... -
Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN; MC PARTLIN, JOSEPH (2007)Background All flour in the USA is fortified with folic acid at a level of 140 ?g/100 g which is estimated to supply an extra 100 ?g daily to the average diet. Some researchers have advocated that this be increased to ... -
Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2008)BACKGROUND: Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns. OBJECTIVE: We ... -
Homocysteine, folate enzymes and neural tube defects
SCOTT, JOHN MARTIN; MOLLOY, ANNE MARIE (1999)Background: The purpose of this study was to characterize total homocysteine (tHcy) levels at birth in preterm and term infants and identify associations with intraventricular hemorrhage (IVH) and other neonatal outcomes ... -
Impact of the MTHFR C677T polymorphism on risk of neural tube defects:case-control study
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (BMJ, 2004)Homozygosity for the T allele of the C677T polymorphism of the gene encoding the folate dependent enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is a risk factor for neural tube defects.1 Both the homozygous (TT) ... -
Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (2009)Molloy AM, Quadros EV, Sequeira JM, Troendle JF, Scott JM, Kirke PN, Mills JL. `Lack of Association between Folate-Receptor Autoantibodies and Neural-Tube Defects? in New England Journal of Medicine, 361, (2), 2009, pp 152-160 -
Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring.
MOLLOY, ANNE MARIE (2007)Compromised cobalamin status during pregnancy may put both mother and child at risk of deficiency during lactation and subsequent development. We investigated whether changes in cobalamin status during pregnancy are ... -
Low vitamin B-12 status and risk of cognitive decline in older adults.
MOLLOY, ANNE MARIE (2007)BACKGROUND: Elevated total homocysteine (tHcy) concentrations have been associated with cognitive impairment, but it is unclear whether low vitamin B-12 or folate status is responsible for cognitive decline. OBJECTIVE: We ... -
Maternal homocysteine before conception and throughout pregnancy predicts fetal homocysteine and birth weight.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (American Association for Clinical Chemistry, 2004)BACKGROUND: Increased homocysteine has been associated with pregnancy complications. METHODS: We investigated prospectively the effect of maternal homocysteine on normal pregnancy outcome. The study included 93 women and ... -
Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (American Academy of Pediatrics, 2009)OBJECTIVE. Folic acid fortification has reduced neural tube defect prevalence by 50% to 70%. It is unlikely that fortification levels will be increased to reduce neural tube defect prevalence further. Therefore, it is ... -
A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss.
MOLLOY, ANNE MARIE; SCOTT, JOHN MARTIN (Oxford University Press, 2005)Low maternal folate or vitamin B12 status has been implicated in numerous pregnancy complications including spontaneous abortion. The primary aim of this study was to test a polymorphism within the trifunctional folate ...