Browsing by Author "MCGETTRICK-DILLON, ANNE"
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How metabolism generates signals during innate immunity and inflammation
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE (2013)The interplay between immunity, inflammation, and metabolic changes is a growing field of research. Toll-like receptors and NOD-like receptors are families of innate immune receptors, and their role in the human immune ... -
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE ANTHONY JOHN (National Academy of Sciences, 2006)TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively in the TLR4 pathway. ... -
Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha
MCGETTRICK-DILLON, ANNE; CORR, SINEAD; PALSSON, EVA; KELLY, VINCENT; O'NEILL, LUKE (2013)Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose ... -
Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene.
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE ANTHONY JOHN (The Biochemical Society, 2004)TRIF [TIR (Toll/interleukin-1 receptor) domain-containing adaptor protein inducing interferon beta; also known as TICAM-1 (TIR-containing adaptor molecule-1)] is a key adaptor for TLR3 (Toll-like receptor 3)- and TLR4-mediated ... -
Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE ANTHONY JOHN; PALSSON, EVA (National Academy of Sciences, 2006)PKC? has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKC? in LPS signaling is unknown. LPS signaling is mediated by Toll-like receptor 4, which uses four ...