Browsing by Author "D'Arcy, Deirdre"
Now showing items 1-9 of 9
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An investigation to optimise teicoplanin therapy in patients with haematological malignancy and Gram-positive infection
Byrne, Catherine. (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)This research was prompted by concerns of Tallaght Hospital, a major teaching hospital in Dublin, Ireland, that the dosage regimen for teicoplanin in patients with haematological malignancy was suboptimal. Three studies ... -
Effect of hydrodynamics on dissolution rate of poorly soluble drugs in the flow through apparatus
Kurapati, Hanumantha Rao (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009) -
Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous hemodiafiltration on different anticoagulant modalities
Munshi, Reema Mohammad (Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Uncertainty remains concerning pharmacokinetics (PK) of antimicrobials in critically ill patients due to the scarcity of data and the variable physiology of the patient cohort. This project incorporates two distinct aims. ... -
In-Vitro Product Performance of Parenteral Drug Products: View of the USP Expert Panel
D'Arcy, Deirdre (2022)Performance testing of parenteral products represents a broad arena of product types, test equipment, and analytical challenges. This Stimuli article is one in a series of Stimuli articles on product performance testing ... -
Investigation of factors affecting dissolution under biorelevant low velocity hydrodynamic conditions, using in vitro and in-silico methods
Liu, Bo (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The goals of the current study were to investigate the effect of hydrodynamics on the dissolution of non-disintegrating compacts in a low velocity environment. This work also studies the impact of hydrodynamics on the ... -
Population pharmacokinetics of teicoplanin and attainment of pharmacokinetic/pharmacodynamic targets in adult patients with haematological malignancy
D'Arcy, Deirdre; Ryder, Sheila; Fennell, Jerome; Mc Hugh, Johnny (2017) -
Use of computational fluid dynamics to investigate the relationship between hydrodynamics and rates of dissolution
D'Arcy, Deirdre (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The hydrodynamics within the paddle (900 ml), basket (900 ml) and Levy beaker (350 ml and 550 ml) (Levy et al., 1965) dissolution apparatuses were simulated using the computational fluid dynamics (CFD) package, Fluent™. ... -
Variability in trough total and unbound teicoplanin concentrations and achievement of therapeutic drug monitoring targets in adult patients with haematological malignancy
D'Arcy, Deirdre; Ryder, Sheila; Fennell, Jerome; Mc Hugh, Johnny (2017)