Browsing by Author "BRACKEN, ADRIAN"
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Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription
BRACKEN, ADRIAN (2005)The E2F family of transcription factors are downstream effectors of the retinoblastoma protein, pRB, pathway and are essential for the timely regulation of genes necessary for cell-cycle progression. Here we describe the ... -
Comparison of BRCAx tumors with BRCA1-, BRCA2-carriers and non-familial breast cancer.
BRACKEN, ADRIAN (2015)Aims Women with inherited pathogenic mutations in the BRCA1 or BRCA2 genes have up to an 85% risk of developing breast cancer in their lifetime. However, only about 20% of familial breast cancer is attributed to mutations ... -
Genome-wide Mapping of Polycomb Target Genes Unravels Their Roles in Cell Fate Transitions.
BRACKEN, ADRIAN (2006)The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Here, we identify their target genes using ... -
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SMYTH, CYRIL; BRACKEN, ADRIAN (2012) -
Polycomb group proteins: navigators of lineage pathways led astray in cancer
BRACKEN, ADRIAN (2009)The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell ... -
Transcriptomics: Unravelling the biology of transcription factors and chromatin remodelers during development and differentiation
BRACKEN, ADRIAN (2009)The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell ... -
The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.
BRACKEN, ADRIAN (2015)PCGF1 encodes one of six human Polycomb RING finger homologs that are linked to transcriptional repression and developmental gene regulation. Individual PCGF proteins define discrete Polycomb Repressor Complex 1 (PRC1) ...