Browsing by Author "O'NEILL, LUKE ANTHONY JOHN"
Now showing items 21-40 of 53
- Sort by:
- title
- issue date
- submit date
- Order:
- ascending
- descending
- Results:
- 5
- 10
- 20
- 40
- 60
- 80
- 100
-
Interleukin-1 activates transcription factor NF kappa B in glial cells
O'NEILL, LUKE ANTHONY JOHN (Portland Press, 1993)Recombinant human interleukin-1 (IL-1) alpha and beta were found to activate a latent cytosolic form of the transcription factor NF kappa B in rat C6 glioma. IL-1 beta was 10 times more potent than IL-1 alpha for this ... -
Interleukin-1 signal transduction: increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4).
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 1990)The post-receptor events which follow the binding of interleukin 1 (IL1) to cells are unclear. The present studies provide evidence for the activation of a guanine nucleotide binding protein (G protein) by IL1 in the ... -
Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2001)Internalin B (InlB), a 630-amino acid protein loosely attached to the surface of Listeria monocytogenes, participates in the entry of the bacterium into mammalian cells. This process requires the activation of phosphoinositide ... -
IRAK-4: a new drug target in inflammation, sepsis and autoimmunity
O'NEILL, LUKE ANTHONY JOHN (American Society for Pharmacology and Experimental Therapeutics, 2002) -
Mal interacts with tumor necrosis factor receptor-associated factor (TRAF)-6 to mediate NF-kappaB activation by toll-like receptor (TLR)-2 and TLR4
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2004)The Toll-interleukin-1 receptor domain-containing adapter Mal (MyD88 adapter-like protein) is involved in Toll-like receptor (TLR)-2 and TLR4 signal transduction. However, no studies have yet identified a function for Mal ... -
Mass Spectrometric Analysis of the Endogenous Type I Interleukin-1 (IL-1) Receptor Signaling Complex Formed after IL-1 Binding Identifies IL-1RAcP, MyD88, and IRAK-4 as the Stable Components
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2007)We investigated the composition of the endogenous ligand-bound type I interleukin-1 (IL-1) receptor (IL-1RI) signaling complex using immunoprecipitation and tandem mass spectrometry. Three proteins with approximate molecular ... -
A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways
O'NEILL, LUKE ANTHONY JOHN (The Protein Society, 2000)Physicochemical properties are potentially useful in predicting functional differences between aligned protein subfamilies. We present a method that considers physicochemical properties from ancestral sequences predicted ... -
MicroRNAs and the resolution phase of in?ammation in macrophages
O'NEILL, LUKE ANTHONY JOHN; ALAM, MUHAMMAD MUSTAFA (John Wiley & Sons, Ltd., 2011)Toll-like receptors (TLRs) signal the presence of pathogens and tissue injury, triggering the inflammatory process in macrophages. The goal of inflammation is to resolve the injury and return the body to homeostasis. ... -
Modulation of innate and acquired immune responses by Escherichia coli heat-labile toxin: distinct pro- and anti-inflammatory effects of the nontoxic AB complex and the enzyme activity
MILLS, KINGSTON; O'NEILL, LUKE ANTHONY JOHN (The American Association of Immunologists, 2000)We have examined the roles of enzyme activity and the nontoxic AB complex of heat-labile toxin (LT) from Escherichia coli on its adjuvant and immunomodulatory properties. LTK63, an LT mutant that is completely devoid of ... -
The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory
O'NEILL, LUKE ANTHONY JOHN (The American Society for Biochemistry and Molecular Biology, 2004)The interleukin-1 receptor-associated kinases (IRAKs) are important downstream signaling components of Toll-like receptors (TLRs). To date, four mammalian IRAKs have been found, namely IRAK-1, IRAK-2, IRAK-4, and IRAK-M. ... -
Mycobacterial PIMs Inhibit Host Inflammatory Responses through CD14-Dependent and CD14-Independent Mechanisms
O'NEILL, LUKE ANTHONY JOHN; KENNY, ELAINE (2011)Mycobacteria develop strategies to evade the host immune system. Among them, mycobacterial LAM or PIMs inhibit the expression of pro-inflammatory cytokines by activated macrophages. Here, using synthetic PIM analogues, we ... -
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
O'NEILL, LUKE ANTHONY JOHN; DUNNE, AISLING (2006)Members of the Toll-like receptor (TLR) family are essential players in activating the host innate immune response against infectious microorganisms. All TLRs signal through Toll/interleukin 1 receptor domain-containing ... -
Myocardial ischemia/reperfusion injury is mediated by leukocytic toll-like receptor-2 and reduced by systemic administration of a novel anti-toll-like receptor-2 antibody.
O'NEILL, LUKE ANTHONY JOHN (2010)Background?Reperfusion therapy for myocardial infarction is hampered by detrimental inflammatory responses partly via Toll-like receptor (TLR) activation. Targeting TLR signaling may optimize reperfusion therapy and enhance ... -
The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE ANTHONY JOHN (National Academy of Sciences, 2006)TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively in the TLR4 pathway. ... -
New insights into the regulation of TLR signaling
O'NEILL, LUKE ANTHONY JOHN (Society of Leukocyte Biology, 2006)Toll-like receptor (TLR) activation is dictated by a number of factors including the ligand itself and the localization of the receptor, in terms of expression profile and subcellular localization and the signal transduction ... -
NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1
O'NEILL, LUKE ANTHONY JOHN; PALSSON MCDERMOTT, EVA; BANAHAN, KATHY; DUNNE, AISLING (2007)Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to activate ... -
Rab39a binds caspase-1 and is required for caspase-1-dependent il-1{beta} secretion
O'NEILL, LUKE ANTHONY JOHN; CREAGH, EMMA (2009)IL-1? is an important pro-inflammatory cytokine that is secreted by unconventional means in a caspase-1-dependent manner. Using a one-step immunoprecipitation approach to isolate endogenous caspase-1 from the monocytic ... -
Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression
O'NEILL, LUKE ANTHONY JOHN (American Society for Biochemistry and Molecular Biology, 2000)We have examined the involvement of Rac1 in nuclear factor kappaB (NFkappaB) activation by interleukin 1 (IL1). IL1 induced a rapid and sustained activation of Rac1 in the thymoma cell line EL4.NOB-1. Transient transfection ... -
Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1
O'NEILL, LUKE ANTHONY JOHN (American Society for Biochemistry and Molecular Biology, 2002)Interleukin-1 (IL-1) activates p38 MAP kinase via the small G protein Ras, and this activity can be down-regulated by another small G protein Rap. Here we have further investigated the role of Ras and Rap in p38 MAPK ... -
Resolution of inflammation: state of the art, definitions and terms
O'NEILL, LUKE ANTHONY JOHN (The Federation of American Societies for Experimental Biology., 2006)A recent focus meeting on Controlling Acute Inflammation was held in London, April 27-28, 2006, organized by D.W. Gilroy and S.D. Brain for the British Pharmacology Society. We concluded at the meeting that a consensus ...