Browsing by Author "DEV, KUMLESH"
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The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures
DEV, KUMLESH (2016)Background BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors, S1PR1 and S1PR5. This drug is currently undergoing clinical trials for the treatment of secondary progressive multiple sclerosis ... -
EBI2 receptor regulates myelin development and inhibits LPC-induced demyelination
DEV, KUMLESH (2017) -
The EBI2 signalling pathway plays a role in cellular crosstalk between astrocytes and macrophages
DEV, KUMLESH (2016)EBI2 is a G protein-coupled receptor activated by oxysterol 7α, 25-dihydroxycholesterol (7α25HC) and regulates T cell-dependant antibody response and B cell migration. We recently found EBI2 is expressed in human astrocytes, ... -
Fingolimod Attenuates Splenocyte-Induced Demyelination in Cerebellar Slice Cultures
DEV, KUMLESH (2014)The family of sphingosine-1-phosphate receptors (S1PRs) is G-protein-coupled, comprised of subtypes S1PR1-S1PR5 and activated by the endogenous ligand S1P. The phosphorylated version of Fingolimod (pFTY720), an oral therapy ... -
Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes
DEV, KUMLESH (2016)Check TCD e-journals(opens in a new window)|View at Publisher| RIS export | Download | Add to List | More... Journal of Neuroinflammation Volume 13, Issue 1, February 08, 2016, Article number 31 Open ... -
Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity.
DEV, KUMLESH (2009)Background Lipid metabolism in mammals is orchestrated by a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control the expression of genes required for the uptake and ... -
Neuropathology in Mice Expressing Mouse Alpha-Synuclein
DEV, KUMLESH (PLoS, 2011)?-Synuclein (?SN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (m?SN), which carries ... -
Pathway specific modulation of S1P1 receptor signalling in rat and human astrocytes.
DEV, KUMLESH (2013)BACKGROUND AND PURPOSE: The sphingosine 1-phosphate receptor subtype 1 (S1P1R) is modulated by phosphorylated FTY720 (pFTY720), which causes S1P1R internalization preventing lymphocyte migration thus limiting autoimmune ... -
The PSD-95/nNOS Complex: New Drugs for Depression?
DOUCET, MARIKA; HARKIN, ANDREW; DEV, KUMLESH (2012)Drug treatment of major depressive disorder is currently limited to the use of agents which influence monoaminergic neuronal transmission including inhibitors of presynaptic transporters and monoamine oxidase. Typically ... -
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis.
DEV, KUMLESH (2008)Peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator-1alpha (PGC-1alpha) is a highly regulated transcriptional coactivator that coordinates energy metabolism in mammals. Misregulation of PGC-1alpha has ... -
The Schizophrenic Faces of PICK1
DEV, KUMLESH (2006)Schizophrenia is a grave psychiatric disorder with psychotic symptoms and an enigmatic etiology. Family studies have strongly indicated that genetic risk factors have a role in this disease. Recent findings, together ... -
Targeting S1P receptors in experimental autoimmune encephalomyelitis in mice improves early deficits in locomotor activity and increases ultrasonic vocalisations
DEV, KUMLESH (2014)Fingolimod (FTY720) is an oral therapy for relapsing remitting multiple sclerosis (MS) and targets sphingosine 1-phosphate receptors (S1PRs). FTY720 also rescues animals from experimental autoimmune encephalomyelitis (EAE), ...