Browsing by Author "DAVIES, ANTHONY"
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Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity
DAVIES, ANTHONY; VOLKOV, YURI; WILLIAMS, YVONNE; PRINA MELLO, ADRIELE; KELLEHER, DERMOT P (2011)Background: Nanomaterials such as SiO2 nanoparticles (SiO2NP) are finding increasing applications in the biomedical and biotechnological fields such as disease diagnostics, imaging, drug delivery, food, cosmetics and ... -
Cytoskeletal re-arrangement in TGF-beta1-induced alveolar epithelial-mesenchymal transition studied by atomic force microscopy and high-content analysis
EHRHARDT, CARSTEN; DAVIES, ANTHONY; MEDINA MARTIN, CARLOS (2012)Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition is acquisition of an elongated cell morphology and establishment ... -
High content screening as high quality assay for biological evaluation of photosensitizers in vitro.
SENGE, MATHIAS; VAZ, GISELA MARGARIDA; PASZKO, EDYTA; DAVIES, ANTHONY (2013)A novel single step assay approach to screen a library of photdynamic therapy (PDT) compounds was developed. Utilizing high content analysis (HCA) technologies several robust cellular parameters were identified, which can ... -
Simple but powerful: Phenanthroline-based small molecules for cellular imaging and cancer screening
SENGE, MATHIAS; SERGEEVA, NATALIA; DAVIES, ANTHONY (2011)A two-step synthetic procedure gives highly fluorescent phenanthroline molecular probes. The compounds localize in the endoplasmic reticulum and their potential as bioactive probes was evaluated. The materials are quickly ...