Browsing by Author "LAWLOR, BRIAN"
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Correlates of frailty in Alzheimer's disease and mild cognitive impairment.
LAWLOR, BRIAN; CUNNINGHAM, CONAL; WALSH, JAMES (2011)The global prevalence of dementia is rising with Alzheimer's disease (AD) accounting for 50–60% of all cases and mild cognitive impairment (MCI) its precursor [1, 2]. Although the clinical hallmark of AD is progressive ... -
Depression, anxiety and cardiovascular disease: Which symptoms are associated with increased risk in community dwelling older adults?
KENNY, ROSE ANNE; O'REGAN, CLAIRE; LAWLOR, BRIAN; SAVVA, GEORGE; CRONIN, HILARY (2012)Depression is a risk factor for Cardiovascular Disease (CVD). It has been reported that somatic symptoms of depression and not cognitive symptoms are associated with increased risk although findings have been inconsistent. ... -
Detection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer's disease etiology using a novel event-based prospective memory task.
COEN, ROBERT; LAWLOR, BRIAN (2009)We investigated the relative discriminatory efficacy of an event-based prospective memory (PM) task, in which specificity of the instructions and perceptual salience of the PM cue were manipulated, compared with two widely ... -
Donepezil Impairs Memory in Healthy Older Subjects: Behavioural, EEG and Simultaneous EEG/fMRI Biomarkers
FAGAN, ANDREW; CASSIDY, SARAH; ROBERTSON, IAN; BALSTERS, JOSHUA; O'CONNELL, REDMOND; LAWLOR, BRIAN; KILCULLEN, SOPHIA; DELMONTE, SONJA; BRENNAN, SABINA; MEANEY, JAMES; BOKDE, ARUN; BRENNAN, SABINA (2011)Rising life expectancies coupled with an increasing awareness of age-related cognitive decline have led to the unwarranted use of psychopharmaceuticals, including acetylcholinesterase inhibitors (AChEIs), by significant ... -
Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation
LAWLOR, BRIAN; COEN, ROBERT; O'MARA, SHANE MICHAEL (2011)Background: Decline in episodic memory is one of the hallmark features of Alzheimer's disease (AD) and is also a defining feature of amnestic Mild Cognitive Impairment (MCI), which is posited as a potential prodrome of ... -
Executive functioning independently predicts self-rated health and improvement in self-rated health over time among community-dwelling older adults
Mchugh J.E.; LAWLOR, BRIAN (2016)Objectives: Self-rated health, as distinct from objective measures of health, is a clinically informative metric among older adults. The purpose of our study was to examine the cognitive and psychosocial factors associated ... -
Exploring the recollective experience during autobiographical memory retrieval in amnestic Mild Cognitive Impairment.
O'MARA, SHANE MICHAEL; LAWLOR, BRIAN; COEN, ROBERT (2010)Autonoetic consciousness refers to the ability to mentally transport oneself back in subjective time to relive elements of, or all, of a past event, and is compromised in the early stages of Alzheimer?s disease (AD). Here, ... -
Failure to demonstrate that memory improvement is due either to aerobic exercise or increased hippocampal volume.
KENNY, ROSE ANNE; LAWLOR, BRIAN (2011)We read with interest the article in PNAS, ?Exercise training increases size of hippocampus and improves memory? by Erickson et al. (1). It is a noteworthy finding that over a 1-y period anterior hippocampal volume ... -
A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
LAWLOR, BRIAN; KENNY, ROSE; ROMERO ORTUNO, ROMAN; WALSH, CATHAL (2010)Background: A frailty paradigm would be useful in primary care to identify older people at risk, but appropriate metrics at that level are lacking. We created and validated a simple instrument for frailty screening in ... -
Frailty, depression and anxiety in later life.
KENNY, ROSE ANNE; LAWLOR, BRIAN; NI MHAOLAIN, AINE; ROMERO-ORTUNO, ROMAN (2012)Background: Anxiety and depression are common in older people but are often missed; to improve detection we must focus on those elderly people at risk. Frailty is a geriatric syndrome inferring increased risk of poor outcomes. ... -
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
GILL, MICHAEL; LAWLOR, BRIAN (2009)We undertook a two-stage genome-wide association study (GWAS) of Alzheimer's disease (AD) involving over 16,000 individuals, the most powerful AD GWAS to date. In stage 1 (3,941 cases and 7,848 controls), we replicated the ... -
The Impact of Cognitive Training and Mental Stimulation on Cognitive and Everyday Functioning of Healthy Older Adults: A Systematic Review and Meta-Analysis
LAWLOR, BRIAN; WALSH, CATHAL; ROBERTSON, IAN; BRENNAN, SABINA (2014)This systematic review and meta-analysis investigates the impact of cognitive training and general mental stimulation on the cognitive and everyday functioning of older adults without known cognitive impairment. We examine ... -
Impaired capacity for autonoetic reliving during autobiographical event recall in mild Alzheimer's disease
COEN, ROBERT; O'MARA, SHANE; LAWLOR, BRIAN (2011)The capacity to mentally travel back in time and relive past events via autonoetic consciousness has been shown to be compromised even in the early stages of Alzheimer's disease (AD). To further understand the unravelling ... -
The Imperative for Disease Modifying Treatments in Alzheimer s Disease
LAWLOR, BRIAN (Medical Association of Ireland, 2009)It is estimated that there are currently as many as 38,000 people with dementia in Ireland and that this figure may exceed 70,000 by 2026.1 Indeed the prevalence of dementia is rising worldwide and it is not surprising ... -
A Multiple Indicators Multiple Causes (MIMIC) model of Behavioural and Psychological Symptoms in Dementia (BPSD).
GILL, MICHAEL; LAWLOR, BRIAN (2011)Introduction Although there is evidence for distinct behavioural sub-phenotypes in Alzheimer's disease (AD), their inter-relationships and the effect of clinical variables on their expression have been little ... -
Orthostatic haemodynamics may be impaired in frailty.
ROMERO-ORTUNO, ROMAN; KENNY, ROSE; LAWLOR, BRIAN (2011)Background: orthostatic hypotension (OH) is a physical sign that reflects a final common pathway of various forms of disordered physiology, which is the hallmark of geriatric frailty. Fried et al. recognise three increasing ... -
Oscillometric measure of blood pressure detects association between orthostatic hypotension and depression in population based study of older adults.
KENNY, ROSE; LAWLOR, BRIAN; CRONIN, HILARY; O'REGAN, CLAIRE (2013) -
The Role of Variation at AßPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease.
GILL, MICHAEL; LAWLOR, BRIAN (2011)Rare mutations in A?PP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether ...