Browsing by Author "HARKIN, ANDREW"
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Exaggerated increases in microglia proliferation, brain inflammatory response and sickness behaviour upon lipopolysaccharide stimulation in non-obese diabetic mice
HARKIN, ANDREW; McGuiness, Barry; Gibney, Sinead M.; Beumer, Wouter; Versnel, Marjan A.; Sillaber, Inge; Drexhage, Hemmo A. (2016)The non-obese diabetic (NOD) mouse, an established model for autoimmune diabetes, shows an exaggerated reaction of pancreas macrophages to inflammatory stimuli. NOD mice also display anxiety when immune-stimulated. Chronic ... -
Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder.
GILL, MICHAEL; HARKIN, ANDREW; MORRIS, DEREK; O'KEANE, VERONICA (2014) -
Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I: C
CUNNINGHAM, COLM; HARKIN, ANDREW (2015)Type I interferons (IFN-I) are expressed in the brain during many inflammatory and neurodegenerative conditions and have multiple effects on CNS function. IFN-I is readily induced in the brain by systemic administration ... -
Noradrenaline acting at beta-adrenoceptors induces expression of IL-1beta and its negative regulators IL-1ra and IL-1RII, and drives an overall anti-inflammatory phenotype in rat cortex
CONNOR, THOMAS JOSEPH; HARKIN, ANDREW; GRIFFIN, EADAOIN; RYAN, KAREN MARGARET (2010)Evidence indicates that noradrenaline elicits anti-inflammatory actions in the central nervous system (CNS), and plays a neuroprotective role where inflammatory events contribute to pathology. Here we examined the ability ... -
Noradrenaline reuptake inhibitors limit neuroinflammation in rat cortex following a systemic inflammatory challenge: implications for depression and neurodegeneration.
HARKIN, ANDREW; CONNOR, THOMAS JOSEPH; RYAN, KAREN MARGARET (Cambridge University Press, 2009)Evidence suggests that noradrenaline has a tonic anti-inflammatory action in the central nervous system (CNS) via its ability to suppress microglial and astrocytic activation, and inhibit production of inflammatory mediators. ... -
The PSD-95/nNOS Complex: New Drugs for Depression?
DOUCET, MARIKA; HARKIN, ANDREW; DEV, KUMLESH (2012)Drug treatment of major depressive disorder is currently limited to the use of agents which influence monoaminergic neuronal transmission including inhibitors of presynaptic transporters and monoamine oxidase. Typically ... -
Soluble beta amyloid evokes alteration in brain norepinephrine levels: Role of nitric oxide and interleukin-1
HARKIN, ANDREW (2015)Strong evidence showed neurotoxic properties of beta amyloid (Aβ) and its pivotal role in the Alzheimer's disease (AD) pathogenesis. Beside, experimental data suggest that Aβ may have physiological roles considering that ...