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dc.contributor.authorLittle, Mark
dc.contributor.authorKelly, Lynne
dc.contributor.authorStevenson, Nigel
dc.date.accessioned2022-05-06T14:10:27Z
dc.date.available2022-05-06T14:10:27Z
dc.date.issued2021
dc.date.submitted2021en
dc.identifier.citationMcKenna E, Mhaonaigh AU, Wubben R, Dwivedi A, Hurley T, Kelly LA, Stevenson NJ, Little MA, Molloy EJ, Neutrophils: Need for Standardized Nomenclature., Frontiers in immunology, 2021, 12:602963en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/98541
dc.descriptionPUBLISHEDen
dc.description.abstractNeutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells have been given many names including phagocytes, polymorphonuclear neutrophils (PMN), granulocytic myeloid derived suppressor cells (G-MDSC), low density neutrophils (LDN) and tumor associated neutrophils (TANS). This lack of standardized nomenclature for neutrophils suggest that biologically distinct populations of neutrophils exist, particularly in disease, when in fact these may simply be a manifestation of the plasticity of the neutrophil as opposed to unique populations. In this review, we profile the surface markers and granule expression of each stage of granulopoiesis to offer insight into how each stage of maturity may be identified. We also highlight the remarkable surface marker expression profiles between the supposed neutrophil populations.en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in immunology;
dc.rightsYen
dc.subjectgranulopoiesisen
dc.subjectNeutrophilsen
dc.subjectinnate immune cellen
dc.subjectNomenclatureen
dc.subjectLow density neutrophilsen
dc.subjectNeutrophil granulesen
dc.titleNeutrophils: Need for Standardized Nomenclatureen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/stevennj
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellyl37
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mlittle
dc.identifier.rssinternalid231613
dc.identifier.doihttp://dx.doi.org/10.3389/fimmu.2021.602963
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0002-6966-9314


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