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dc.contributor.authorMc Lysaght, Aoife
dc.date.accessioned2022-03-28T11:39:26Z
dc.date.available2022-03-28T11:39:26Z
dc.date.issued2021
dc.date.submitted2021en
dc.identifier.citationNakatani Y, Shingate P, Ravi V, Pillai NE, Prasad A, McLysaght A, Venkatesh B., Reconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution, Nature communications, 2021, 12, 1, 4489en
dc.identifier.issn2041-1723
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/98373
dc.descriptionPUBLISHEDen
dc.description.abstractAncient polyploidization events have had a lasting impact on vertebrate genome structure, organization and function. Some key questions regarding the number of ancient polyploidization events and their timing in relation to the cyclostome-gnathostome divergence have remained contentious. Here we generate de novo long-read-based chromosome-scale genome assemblies for the Japanese lamprey and elephant shark. Using these and other representative genomes and developing algorithms for the probabilistic macrosynteny model, we reconstruct high-resolution proto-vertebrate, proto-cyclostome and proto-gnathostome genomes. Our reconstructions resolve key questions regarding the early evolutionary history of vertebrates. First, cyclostomes diverged from the lineage leading to gnathostomes after a shared tetraploidization (1R) but before a gnathostome-specific tetraploidization (2R). Second, the cyclostome lineage experienced an additional hexaploidization. Third, 2R in the gnathostome lineage was an allotetraploidization event, and biased gene loss from one of the subgenomes shaped the gnathostome genome by giving rise to remarkably conserved microchromosomes. Thus, our reconstructions reveal the major evolutionary events and offer new insights into the origin and evolution of vertebrate genomes.en
dc.format.extent4489en
dc.language.isoenen
dc.relation.ispartofseriesNature communications;
dc.relation.ispartofseries12;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectAncient polyploidizationen
dc.subjectvertebrate genome structureen
dc.subjectgenerate de novo long-read-based chromosome-scale genome assembliesen
dc.titleReconstruction of proto-vertebrate, proto-cyclostome and proto-gnathostome genomes provides new insights into early vertebrate evolution.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mclysaga
dc.identifier.rssinternalid236087
dc.identifier.doihttp://dx.doi.org/10.1038/s41467-021-24573-z
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0003-2552-6220


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