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dc.contributor.authorDoherty, Derek
dc.contributor.authorMelo, Ashanty M.
dc.contributor.authorTaher, Nawal AB.
dc.contributor.authorMolloy, Eleanor J.
dc.date.accessioned2022-02-24T09:02:47Z
dc.date.available2022-02-24T09:02:47Z
dc.date.issued2021
dc.date.submitted2021en
dc.identifier.citationMelo AM, Taher NA, Doherty DG, Molloy EJ, The role of lymphocytes in neonatal encephalopathy, Brain Behavior and Immunity Health, 2021 Oct 20;18:100380en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/98169
dc.descriptionPUBLISHEDen
dc.description.abstractNeonatal encephalopathy is a syndrome characterised by abnormal neurological function often caused by a hypoxic insult during childbirth. Triggers such as hypoxia-ischaemia result in the release of cytokines and chemokines inducing the infiltration of neutrophils, natural killer cells, B cells, T cells and innate T cells into the brain. However, the role of these cells in the development of the brain injury is poorly understood. We review the mechanisms by which lymphocytes contribute to brain damage in NE. NK, T and innate T cells release proinflammatory cytokines contributing to the neurodegeneration in the secondary and tertiary phase of injury, whereas B cells and regulatory T cells produce IL-10 protecting the brain in NE. Targeting lymphocytes may have therapeutic potential in the treatment of NE in terms of management of inflammation and brain damage, particularly in the tertiary or persistent phases.en
dc.format.extent100380en
dc.language.isoenen
dc.relation.ispartofseriesBrain Behavior and Immunity Health;
dc.relation.ispartofseries18;
dc.rightsYen
dc.subjectBlood-brain barrier, BBBen
dc.subjectTNF-αen
dc.subjectTumour necrosis factor-alphaen
dc.subjectHypoxia-ischaemia encephalopathy, HIEen
dc.subjectHypoxia-ischaemia, HIen
dc.subjectImmune responseen
dc.subjectLymphocytesen
dc.subjectNeonatal encephalopathy, NEen
dc.subjectRegulatory T cells, Tregsen
dc.subjectT cell receptors, TCRsen
dc.subjectT helper, Then
dc.subjectTherapeutic hypothermia, THen
dc.subjectWhite Matter Injury, WMIen
dc.subjectActivating transcription factor-6, ATF6en
dc.subjectCentral nervous system, CNSen
dc.subjectGranulocyte-macrophage colony-stimulating factor, GM-CSFen
dc.subjectInterleukin, ILen
dc.subjectMajor histocompatibility complex, MHCen
dc.subjectNatural killer, NK cellsen
dc.titleThe role of lymphocytes in neonatal encephalopathyen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dohertde
dc.identifier.rssinternalid238592
dc.identifier.doi10.1016/j.bbih.2021.100380
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.identifier.rssurihttps://pubmed.ncbi.nlm.nih.gov/34755125/
dc.identifier.orcid_id0000-0002-4394-658X
dc.status.accessibleNen


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