Tissue distribution of γδ T cell subsets in oesophageal adenocarcinoma
Item Type:Journal Article
Citation:Ashanty M.Melo, Eimear Mylod, Vivienne Fitzgerald, Noel E.Donlon, Dearbhla M. Murphy, Emma K.Foley, Anshul Bhardwaj, John V.Reynolds, Derek G.Doherty, Joanne Lysaght, Margaret R. Dunne, Melissa J. Conroy, Tissue distribution of γδ T cell subsets in oesophageal adenocarcinoma, Clinical Immunology, 229, 2021
Melo, Conroy Clin Immunol gd in OAC.pdf (PDF) 3.093Mb
The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) is an obesity-associated malignancy with increasing prevalence, dismal prognosis, and severely dysregulated immune processes. We previously reported that αβ T cells migrate to omentum and liver in OAC and contribute to inflammation in these tissues. Here, we assessed the tissue distribution and phenotype of gamma/delta (γδ) T cells in the blood, omentum, liver and tumour of OAC patients. Our data show that the Vδ1 and Vδ3 subsets of γδ T cells are most prevalent in omentum and liver of OAC patients. Furthermore, γδ T cells are predominantly pro-inflammatory in these tissues, and co-express IFN-γ and IL-17. Moreover, γδ T cells exhibit cytotoxic capabilities in OAC omentum and liver. This study provides the first indication that γδ T cells contribute to obesity-associated inflammation in OAC and might be exploited therapeutically.
Type of material:Journal Article
Series/Report no:Clinical Immunology
Availability:Full text available