Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors
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Journal ArticleDate:
2021Access:
openAccessCitation:
Freeman F.E., Burdis R., Kelly D.J., Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors, Trends in Molecular Medicine, 27, (7), 2021, p700 - 711, p700-711Download Item:
Freeman et al._TMM_Manuscript_Rev 2 - Editorial review.docx (Unknown) 1.836Mb
Abstract:
Regenerating large bone defects remains a significant clinical challenge, motivating increased interest in additive manufacturing and 3D bioprinting to engineer superior bone graft substitutes. 3D bioprinting enables different biomaterials, cell types and growth factors to be combined to develop patient-specific implants capable of directing functional bone regeneration. Current approaches to bioprinting such implants fall into one of two categories, each with their own advantages and limitations. Firstly, are those that can be 3D bioprinted and then directly implanted into the body, and secondly those that require further in vitro culture after bioprinting to engineer more mature tissues prior to implantation. This review overviews the key concepts, challenges, and applications of both strategies for regenerating damaged and diseased bone.
Sponsor
Grant Number
European Union (EU)
839150
Author's Homepage:
http://people.tcd.ie/freemanfhttp://people.tcd.ie/kellyd9
Description:
PUBLISHED
Author: Freeman, Fiona; Kelly, Daniel
Type of material:
Journal ArticleSeries/Report no:
Trends in Molecular Medicine;27;
7;
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Full text availableKeywords:
Bioprinting, Bone Regeneration, Tissue Engineering, BoneSubject (TCD):
Next Generation Medical Devices , BONE REGENERATION , Tissue EngineeringDOI:
http://dx.doi.org/10.1016/j.molmed.2021.05.001ISSN:
1471499X 14714914Licences: