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dc.contributor.authorMc Lysaght, Aoife
dc.date.accessioned2021-03-23T10:21:57Z
dc.date.available2021-03-23T10:21:57Z
dc.date.issued2015
dc.date.submitted2015en
dc.identifier.citationMcLysaght A, Guerzoni D. New genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovation. Philosophical Transactions Royal Society London B, Biological Sciences, 2015 Sep 26;370(1678):20140332en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/95834
dc.descriptionPUBLISHEDen
dc.description.abstractThe origin of novel protein-coding genes de novo was once considered so improbable as to be impossible. In less than a decade, and especially in the last five years, this view has been overturned by extensive evidence from diverse eukaryotic lineages. There is now evidence that this mechanism has contributed a significant number of genes to genomes of organisms as diverse as Saccharomyces, Drosophila, Plasmodium, Arabidopisis and human. From simple beginnings, these genes have in some instances acquired complex structure, regulated expression and important functional roles. New genes are often thought of as dispensable late additions; however, some recent de novo genes in human can play a role in disease. Rather than an extremely rare occurrence, it is now evident that there is a relatively constant trickle of proto-genes released into the testing ground of natural selection. It is currently unknown whether de novo genes arise primarily through an ‘RNA-first’ or ‘ORF-first’ pathway. Either way, evolutionary tinkering with this pool of genetic potential may have been a significant player in the origins of lineage-specific traits and adaptations.en
dc.language.isoenen
dc.relation.ispartofseriesPhilosophical transactions of the Royal Society of London. Series B, Biological sciences;
dc.relation.ispartofseries370;
dc.relation.ispartofseries1678;
dc.rightsYen
dc.subjectDe novo genesen
dc.subjectEvolutionen
dc.subjectOpen reading frameen
dc.subjectProto-genesen
dc.titleNew genes from non-coding sequence: the role of de novo protein-coding genes in eukaryotic evolutionary innovationen
dc.typeJournal Articleen
dc.contributor.sponsorEuropean Research Council (ERC)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mclysaga
dc.identifier.rssinternalid106122
dc.identifier.doihttp://dx.doi.org/10.1098/rstb.2014.0332
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeGenes & Societyen
dc.subject.TCDTagComputational Biologyen
dc.subject.TCDTagEVOLUTIONen
dc.subject.TCDTagGenomes, Genomicsen
dc.identifier.orcid_id0000-0003-2552-6220


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