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dc.contributor.authorAhearne, Marken
dc.date.accessioned2021-03-16T16:41:43Z
dc.date.available2021-03-16T16:41:43Z
dc.date.issued2020en
dc.date.submitted2020en
dc.identifier.citationMadden, P.W. and Klyubin, I. and Ahearne, M.J., Silk fibroin safety in the eye: A review that highlights a concern, BMJ Open Ophthalmology, 5, 1, 2020en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/95716
dc.descriptionPUBLISHEDen
dc.description.abstractThe biomedical use of silk as a suture dates back to antiquity. Fibroin is the structural element that determines the strength of silk and here we consider the safety of fibroin in its role in ophthalmology. The high mechanical strength of silk meant sufficiently thin threads could be made for eye microsurgery, but such usage was all but superseded by synthetic polymer sutures, primarily because silk in its entirety was more inflammatory. Significant immunological response can normally be avoided by careful manufacturing to provide high purity fibroin, and it has been utilised in this form for tissue engineering an array of fibre and film substrata deployed in research with cells of the eye. Films of fibroin can also be made transparent, which is a required property in the visual pathway. Transparent layers of corneal epithelial, stromal and endothelial cells have all been demonstrated with maintenance of phenotype, as have constructs supporting retinal cells. Fibroin has a lack of demonstrable infectious agent transfer, an ability to be sterilised and prepared with minimal contamination, long-term predictable degradation and low direct cytotoxicity. However, there remains a known ability to be involved in amyloid formation and potential amyloidosis which, without further examination, is enough to currently question whether fibroin should be employed in the eye given its innervation into the brain.en
dc.language.isoenen
dc.relation.ispartofseriesBMJ Open Ophthalmologyen
dc.relation.ispartofseries5en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectlow direct cytotoxicityen
dc.subjectsilk as a sutureen
dc.subjectFibroinen
dc.titleSilk fibroin safety in the eye: A review that highlights a concernen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/ahearnmen
dc.identifier.rssinternalid225936en
dc.identifier.doihttp://dx.doi.org/10.1136/bmjophth-2020-000510en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber15/ERC/3269en
dc.identifier.orcid_id0000-0002-4540-4434en


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