Show simple item record

dc.contributor.authorO'Neill, Luke
dc.date.accessioned2021-03-01T10:05:46Z
dc.date.available2021-03-01T10:05:46Z
dc.date.issued2020
dc.date.submitted2020en
dc.identifier.citationHams, E., Roberts, J., Bermingham, R., Hogan, A.E., O’Shea, D., O’Neill, L., Fallon, P.G., Role for RetinoicAcid-Related Orphan Receptor Alpha(RORα) Expressing Macrophages inDiet-Induced Obesity, Frontiers in Immunology, 2020, 11:1966en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/95417
dc.description.abstractThe transcription factor RORα plays an important role in regulating circadian rhythm, inflammation, metabolism, and cellular development. Herein we show a role for RORα-expressing macrophages in the adipose tissue in altering the metabolic state of mice on a high-fat diet. The expression of Rora and RORA is elevated in white adipose tissue from obese mice and humans when compared to lean counterparts. When fed a high-fat diet Rora reporter mice revealed increased expression of Rora-YFP in macrophages in white adipose tissue deposits. To further define the potential role for Rora-expressing macrophages in the generation of an aberrant metabolic state Rorafl/flLysMCre/+ mice, which do not express Rora in myeloid cells, were maintained on a high-fat diet, and metabolic parameters assessed. These mice had significantly impaired weight gain and improved metabolic parameters in comparison to Rorafl/fl control mice. Further analysis of the immune cell populations within white adipose tissue deposits demonstrates a decrease in inflammatory adipose tissue macrophages (ATM). In obese reporter mouse there was increased in Rora-YFP expressing ATM in adipose tissue. Analysis of peritoneal macrophage populations demonstrates that within the peritoneal cavity Rora-expression is limited to myeloid-derived macrophages, suggesting a novel role for RORα in macrophage development and activation, which can impact on metabolism, and inflammation.en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in Immunology;
dc.relation.ispartofseries11;
dc.relation.ispartofseries1966;
dc.rightsYen
dc.subjectRORαen
dc.subjectMacrophageen
dc.subjectInflammationen
dc.subjectMetabolismen
dc.subjectObesityen
dc.subject.lcshmacrophageen
dc.subject.lcshRORαen
dc.subject.lcshcircadian rhythmen
dc.titleRole for Retinoic Acid-Related Orphan Receptor Alpha (RORα) Expressing Macrophages in Diet-Induced Obesityen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneill
dc.identifier.rssinternalid224568
dc.identifier.doihttp://dx.doi.org/10.3389/fimmu.2020.01966
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber10/IN.1/B3004en
dc.contributor.sponsorGrantNumber15/SIRG/3473en


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record