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dc.contributor.authorColavita, Paula
dc.contributor.authorScanlan, Eoin
dc.date.accessioned2020-06-29T16:10:53Z
dc.date.available2020-06-29T16:10:53Z
dc.date.issued2016
dc.date.submitted2016en
dc.identifier.citationEsteban-Tejeda, L., Duff, T., Ciapetti, G., Angione, M. D., Myles, A., Vasconcelos, J. M., Scanlan, E. M., Colavita, P. E., Stable hydrophilic poly(dimethylsiloxane) via glycan surface functionalization, Polymer, 2016, 106, 1 - 7en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/92872
dc.descriptionPUBLISHEDen
dc.description.abstractPolydimethylsiloxane (PDMS) is an extremely important and versatile polymeric material for biomedical and microfluidic devices due to a range of desirable properties. Control of the hydrophilicity of PDMS surfaces is of significant interest due to the potential for developing surfaces with tunable protein adsorption or cell adhesion properties. We report the formation of stable hydrophilic PDMS surfaces by covalent modification with glycans via aryldiazonium chemistry. The PDMS surface was modified by a two step-process including an activation of the PDMS surface, followed by reaction with aryldiazonium glycosides in aqueous solution. The functionalized PDMS was characterized by atomic force microscopy, infrared and X-ray photoelectron spectroscopy, water contact angle measurements and fluorescence microscopy. Our results demonstrate that glycans immobilized via this methodology have the dual function of imparting hydrophilicity and stabilizing the modified surface against hydrophobic recovery. Importantly, the presentation of thus immobilized glycosides makes them available to specific lectin-glycan binding interactions at the polymer-solution interface while, in the absence of specific binding interactions, leads to a reduction in albumin adsorption. This approach provides a novel and efficient route to stable hydrophilic PDMS surfaces with a broad range of applications.en
dc.format.extent1en
dc.format.extent7en
dc.language.isoenen
dc.relation.ispartofseriesPolymer;
dc.relation.ispartofseries106;
dc.rightsYen
dc.subjectPDMSen
dc.subjectCarbohydratesen
dc.subjectFunctionalizationen
dc.titleStable hydrophilic poly(dimethylsiloxane) via glycan surface functionalizationen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/colavitp
dc.identifier.peoplefinderurlhttp://people.tcd.ie/scanlae
dc.identifier.rssinternalid146037
dc.identifier.doihttps://doi.org/10.1016/j.polymer.2016.10.044
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0003-1008-2874


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