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dc.contributor.authorBudanov, Andrei
dc.contributor.authorLee, Jun Hee
dc.contributor.authorKarin, Michael
dc.date.accessioned2020-02-28T11:45:13Z
dc.date.available2020-02-28T11:45:13Z
dc.date.issued2013
dc.date.submitted2013en
dc.identifier.citationLee, J.H., Budanov, A.V. & Karin, M., Sestrins orchestrate cellular metabolism to attenuate aging, Cell Metabolism, 18, 6, 2013, 792 - 801en
dc.identifier.otherY
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1550413113003446?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/2262/91647
dc.description.abstractThe Sestrins constitute a family of evolutionarily conserved stress-inducible proteins that suppress oxidative stress and regulate AMP-dependent protein kinase (AMPK)-mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important regulators of metabolic homeostasis. Accordingly, inactivation of Sestrin genes in invertebrates resulted in diverse metabolic pathologies, including oxidative damage, fat accumulation, mitochondrial dysfunction, and muscle degeneration, that resemble accelerated tissue aging. Likewise, Sestrin deficiencies in mice led to accelerated diabetic progression upon obesity. Further investigation of Sestrin function and regulation should provide new insights into age-associated metabolic diseases, such as diabetes, myopathies, and cancer.en
dc.format.extent792en
dc.format.extent801en
dc.language.isoenen
dc.relation.ispartofseriesCell Metabolism;
dc.relation.ispartofseries18;
dc.relation.ispartofseries6;
dc.rightsYen
dc.subjectSestrinsen
dc.subjectOxidative stressen
dc.subjectMetabolismen
dc.subjectMetabolic diseasesen
dc.titleSestrins orchestrate cellular metabolism to attenuate agingen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/budanova
dc.identifier.rssinternalid156248
dc.identifier.doi10.1016/j.cmet.2013.08.018
dc.rights.ecaccessrightsopenAccess
dc.relation.sourcewebpageen
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeCanceren
dc.subject.TCDTagPHOSPHORYLATIONen
dc.relation.sourceurihttps://www.sciencedirect.com/science/article/pii/S1550413113003446en
dc.identifier.orcid_id0000-0002-7943-1000
dc.subject.darat_impairmentAge-related disabilityen
dc.subject.darat_thematicHealthen
dc.status.accessibleNen


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