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dc.contributor.authorBudanov, Andrei
dc.contributor.authorDing, Boxiao
dc.contributor.authorParmigiani, Anita
dc.contributor.authorDivakaruni, Ajit S.
dc.contributor.authorArcher, Kellie
dc.contributor.authorMurphy, Anne N.
dc.date.accessioned2020-02-27T17:25:36Z
dc.date.available2020-02-27T17:25:36Z
dc.date.issued2016
dc.date.submitted2016en
dc.identifier.citationDing, B., Parmigiani, A., Divakaruni, A.S., Archer, K., Murphy, A.N. & Budanov, A.V., Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death., Scientific Reports, 6, 22538, 2016, 14en
dc.identifier.issn2045-2322
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/91633
dc.description.abstractSestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by different stress insults, which diminish ATP production and induce energetic stress in the cells. Glucose is a critical substrate for ATP production utilized via glycolysis and mitochondrial respiration as well as for glycosylation of newly synthesized proteins in the endoplasmic reticulum (ER) and Golgi. Thus, glucose starvation causes both energy deficiency and activation of ER stress followed by the unfolding protein response (UPR). Here, we show that UPR induces Sestrin2 via ATF4 and NRF2 transcription factors and demonstrate that Sestrin2 protects cells from glucose starvation-induced cell death. Sestrin2 inactivation sensitizes cells to necroptotic cell death that is associated with a decline in ATP levels and can be suppressed by Necrostatin 7. We propose that Sestrin2 protects cells from glucose starvation-induced cell death via regulation of mitochondrial homeostasis.en
dc.format.extent14en
dc.language.isoenen
dc.relation.ispartofseriesScientific Reports;
dc.relation.ispartofseries6;
dc.relation.ispartofseries22538;
dc.rightsYen
dc.subjectSestrinsen
dc.subjectGlucoseen
dc.subjectCell deathen
dc.titleSestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell deathen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/budanova
dc.identifier.rssinternalid156263
dc.identifier.doi10.1038/srep22538
dc.rights.ecaccessrightsopenAccess
dc.relation.sourcewebpageen
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeCanceren
dc.subject.TCDTagCELL DEATHen
dc.subject.TCDTagMETABOLISMen
dc.relation.sourceurihttps://www.nature.com/articles/srep22538en
dc.identifier.orcid_id0000-0002-7943-1000
dc.subject.darat_impairmentAge-related disabilityen
dc.subject.darat_thematicHealthen
dc.status.accessibleNen


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