dc.contributor.author | Senge, Mathias | |
dc.contributor.author | Donohue, Claire | |
dc.contributor.author | Arnaut, Luís G. | |
dc.contributor.author | Gomes-da-Silva, Lígia C. | |
dc.date.accessioned | 2020-02-05T15:39:00Z | |
dc.date.available | 2020-02-05T15:39:00Z | |
dc.date.issued | 2019 | |
dc.date.submitted | 2019 | en |
dc.identifier.citation | Donohue, C., Senge, M.O., Arnaut, L.G. & Gomes-da-Silva, L.C., Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity, 2019, Biochimica et Biophysica Acta - Reviews on Cancer, 1872, 2 | en |
dc.identifier.other | Y | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0304419X19300861?via%3Dihub | |
dc.identifier.uri | http://hdl.handle.net/2262/91458 | |
dc.description.abstract | Photodynamic therapy is a promising approach for cancer treatment that relies on the
administration of a photosensitizer followed by tumor illumination. The generated oxidative
stress may activate multiple mechanism of cell death which are counteracted by adaptive
stress responses that target homeostasis rescue. The present renaissance of PDT was
leveraged by the acknowledgment that this therapy has an immediate impact locally, in the
illumination volume, but that subsequently it may elicit immune responses with systemic
impact. The investigation of the mechanisms of cell death under the oxidative stress of PDT
is of paramount importance to understand how the immune system is activated and,
ultimately, to make PDT a more appealing/relevant therapeutic option. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Biochimica et Biophysica Acta - Reviews on Cancer; | |
dc.relation.ispartofseries | 1872; | |
dc.relation.ispartofseries | 2; | |
dc.rights | Y | en |
dc.subject | Photodynamic therapy | en |
dc.subject | Oxidative stress | en |
dc.subject | Integrated stress response | en |
dc.subject | Endoplasmic reticulum stress | en |
dc.subject | Nrf2 antioxidant pathway | en |
dc.subject | Cell death | en |
dc.subject | Immunogenic cell death and anti-tumour immunity | en |
dc.title | Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity | en |
dc.type | Journal Article | en |
dc.contributor.sponsor | Science Foundation Ireland | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/sengem | |
dc.identifier.rssinternalid | 211419 | |
dc.identifier.doi | http://dx.doi.org/10.1016/j.bbcan.2019.07.003 | |
dc.rights.ecaccessrights | openAccess | |
dc.contributor.sponsorGrantNumber | SFI P.I. 13/IA/1894 | en |