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dc.contributor.authorSenge, Mathias
dc.contributor.authorWiehe, Arno
dc.contributor.authorO'Brien, Jessica M.
dc.date.accessioned2020-02-05T12:30:58Z
dc.date.available2020-02-05T12:30:58Z
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationWiehe, A., O'Brien, J.M. & Senge, M.O., Trends and targets in antiviral phototherapy, 2019, Photochemical and Photobiological Sciences, 18, 11en
dc.identifier.otherY
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2019/PP/C9PP00211A#!divAbstract
dc.identifier.urihttp://hdl.handle.net/2262/91455
dc.description.abstractPhotodynamic therapy (PDT) is a well‐established treatment option in the treatment of certain cancerous and pre‐cancerous lesions. Though best‐known for its application in tumor therapy, historically the photodynamic effect was first demonstrated against bacteria at the beginning of the 20th century. Today, in light of spreading antibiotic resistance and the rise of new infections, this photodynamic inactivation (PDI) of microbes, such as bacteria, fungi, and viruses, is gaining considerable attention. This review focuses on the PDI of viruses as an alternative treatment in antiviral therapy, but also as a means of viral decontamination, covering mainly the literature of the last decade. The PDI of viruses shares the general action mechanism of photodynamic applications: the irradiation of a dye with light and the subsequent generation of reactive oxygen species (ROS) which are the effective phototoxic agents damaging virus targets by reacting with viral nucleic acids, lipids and proteins. Interestingly, a light‐independent antiviral activity has also been found for some of these dyes. This review covers the compound classes employed in the PDI of viruses and their various areas of use. In the medical area, currently two fields stand out in which the PDI of viruses has found broader application: the purification of blood products and the treatment of human papilloma virus manifestations. However, the PDI of viruses has also found interest in such diverse areas as water and surface decontamination, and biosafetyen
dc.format.extent2565-2612en
dc.language.isoenen
dc.relation.ispartofseriesPhotochemical and Photobiological Sciences;
dc.relation.ispartofseries18;
dc.relation.ispartofseries11;
dc.rightsYen
dc.subjectPhotodynamic therapy (PDT)en
dc.subjectAntiviral therapyen
dc.subjectDecontaminationen
dc.subjectBiosafetyen
dc.subject.lcshPhotodynamic therapy (PDT)en
dc.titleTrends and targets in antiviral phototherapyen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengem
dc.identifier.rssinternalid211421
dc.identifier.doihttp://dx.doi.org/10.1039/c9pp00211a
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberIvP 13/IA/1894en


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