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dc.contributor.authorSenge, Mathias
dc.contributor.authorCallaghan, Susan
dc.contributor.authorFilatov, Mikhail A.
dc.contributor.authorSavoie, Huguette
dc.contributor.authorBoyle, Ross W.
dc.date.accessioned2020-02-04T16:47:55Z
dc.date.available2020-02-04T16:47:55Z
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationCallaghan, S., Filatov, M.A., Savoie, H., Boyle, R.W. & Senge, M.O., In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy, 2019, Photochemical and Photobiological Sciences, 18, 2en
dc.identifier.otherY
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2019/PP/C8PP00402A#!divAbstract
dc.identifier.urihttp://hdl.handle.net/2262/91438
dc.description.abstractThe facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light.en
dc.format.extent495-504en
dc.language.isoenen
dc.relation.ispartofseriesPhotochemical and Photobiological Sciences;
dc.relation.ispartofseries18;
dc.relation.ispartofseries2;
dc.rightsYen
dc.subjectBODIPYen
dc.subjectHeavy atom-free BODIPY-anthracene, -pyrene dyadsen
dc.subjectPhotodynamic therapyen
dc.titleIn vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapyen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengem
dc.identifier.rssinternalid206059
dc.identifier.doihttp://dx.doi.org/10.1039/C8PP00402A
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumbervP 13/IA/1894en


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