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dc.contributor.authorKelly, Daniel
dc.contributor.authorO'Brien, Katie L.
dc.date.accessioned2020-01-21T12:49:27Z
dc.date.available2020-01-21T12:49:27Z
dc.date.created2019en
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationO'Brien, K.L. & Kelly, D., Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells, 2019, Acta Biomaterialia, 88en
dc.identifier.otherY
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1742706119301552?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/2262/91352
dc.descriptionPUBLISHEDen
dc.description.abstractControlling the phenotype of transplanted stem cells is integral to ensuring their therapeutic efficacy. Hypoxia is a known regulator of stem cell fate, the effects of which can be mimicked using hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors such as dimethyloxalylglycine (DMOG). By releasing DMOG from mesenchymal stem cell (MSC) laden alginate hydrogels, it is possible to stabilize HIF-1α and enhance its nuclear localization. This correlated with enhanced chondrogenesis and a reduction in the expression of markers associated with chondrocyte hypertrophy, as well as increased SMAD 2/3 nuclear localization in the encapsulated MSCs. In vivo, DMOG delivery significantly reduced mineralisation of the proteoglycan-rich cartilaginous tissue generated by MSCs within alginate hydrogels loaded with TGF-β3 and BMP-2. Together these findings point to the potential of hypoxia mimicking hydrogels to control the fate of stem cells following their implantation into the bodyen
dc.format.extent314en
dc.format.extent324en
dc.language.isoenen
dc.relation.ispartofseriesActa Biomaterialia;
dc.relation.ispartofseries88;
dc.rightsYen
dc.subjectTransplanted stem cellsen
dc.subjectMesenchymal stem cellsen
dc.subjectHydrogelen
dc.subjectStem cell fateen
dc.subjectDMOGen
dc.subjectOxygen tensionen
dc.subjectHypoxiaen
dc.subjectChondrogenesisen
dc.subjectHypertrophyen
dc.titleHypoxia mimicking hydrogels to regulate the fate of transplanted stem cellsen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/kellyd9
dc.identifier.rssinternalid204466
dc.identifier.doihttp://dx.doi.org/10.1016/j.actbio.2019.02.042
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber12/US/I2489en
dc.contributor.sponsorGrantNumber12/IA/1554en
dc.identifier.orcid_id0000-0003-4091-0992


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