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dc.contributor.authorMcgouran, Joannaen
dc.date.accessioned2020-01-10T16:35:00Z
dc.date.available2020-01-10T16:35:00Z
dc.date.issued2020en
dc.date.submitted2020en
dc.identifier.citationTaylor, N.C. McGouran, J.F., Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery, Frontiers in Chemistry, 7, 914, 2020, 1-9en
dc.identifier.otherYen
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fchem.2019.00914/full
dc.identifier.urihttp://hdl.handle.net/2262/91295
dc.descriptionPUBLISHEDen
dc.description.abstractThe regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making its tight regulation key to optimal cell function. Activity based protein profiling has emerged as a powerful technique to study these important enzymes. With around 100 deubiquitinating enzymes and 600 ubiquitin ligases in the human genome targeting a subclass of these enzymes or even a single enzyme is a compelling strategy to unpick this complex system. In this review we will discuss different approaches adopted, including activity-based probes centered around ubiquitin-protein, ubiquitin-peptide and mutated ubiquitin scaffolds. We examine challenges faced and opportunities presented to increase specificity in activity-based protein profiling of the ubiquitin conjugation/deconjugation machinery.en
dc.format.extent1-9en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in Chemistryen
dc.relation.ispartofseries7en
dc.relation.ispartofseries914en
dc.rightsYen
dc.subjectActivity-based protein profilingen
dc.subjectUbiquitinen
dc.subjectProtein modificationen
dc.subjectDeubiquitinating enzymesen
dc.subjectProbeen
dc.titleStrategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machineryen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jmcgouraen
dc.identifier.rssinternalid209810en
dc.identifier.doihttps://doi.org/10.3389/fchem.2019.00914
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeCanceren
dc.identifier.orcid_id0000-0002-9349-2141en
dc.status.accessibleNen


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