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dc.contributor.authorGAUL, ROBERT
dc.contributor.authorLally, Caitriona
dc.contributor.authorNolan, David
dc.date.accessioned2019-12-20T12:02:03Z
dc.date.available2019-12-20T12:02:03Z
dc.date.issued2018
dc.date.submitted2018en
dc.identifier.citationGaul, R., Nolan, D. & Lally, C., The use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivo, Journal of Biomechanics, 81, 2018en
dc.identifier.issn0021-9290
dc.identifier.otherY
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0021929018307711?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/2262/91219
dc.descriptionPUBLISHEDen
dc.description.abstractCollagen is the predominant load bearing component in many soft tissues including arterial tissue and is therefore critical in determining the mechanical integrity of such tissues. Degradation of collagen fibres is hypothesized to be a strain dependent process whereby the rate of degradation is affected by the magnitude of strain applied to the collagen fibres. The aim of this study is to investigate the ability of small angle light scattering (SALS) imaging to identify strain dependent degradation of collagen fibres in arterial tissue ex vivo, and determine whether a strain induced protection mechanism exists in arterial tissue as observed in pure collagen and other collagenous tissues. SALS was used in combination with histological and second harmonic generation (SHG) analysis to determine the collagen fibre architecture in arterial tissue subjected to strain directed degradation. SALS alignment analysis identified statistically significant differences in fibre alignment depending on the strain magnitude applied to the tissue. These results were also observed using histology and SHG. Our findings suggest a strain protection mechanism may exist for arterial collagen at intermediate strain magnitudes between 0% and 25%. These findings may have implications for the onset and progression of arterial disease where changes in the mechanical environment of arterial tissue may lead to changes in the collagen degradation rate.en
dc.language.isoenen
dc.relation.ispartofseriesJournal of Biomechanics;
dc.relation.ispartofseries81;
dc.rightsYen
dc.subjectCollagen degradationen
dc.subjectSmall angle light scatteringen
dc.titleThe use of small angle light scattering in assessing strain induced collagen degradation in arterial tissue ex vivoen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.contributor.sponsorIrish Research Council (IRC)en
dc.contributor.sponsorEuropean Research Council (ERC)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/rgaul
dc.identifier.peoplefinderurlhttp://people.tcd.ie/dnolan4
dc.identifier.peoplefinderurlhttp://people.tcd.ie/lallyca
dc.identifier.rssinternalid192787
dc.identifier.doihttps://doi.org/10.1016/j.jbiomech.2018.10.006
dc.relation.ecprojectidinfo:eu-repo/grantAgreement/EC/FP7/637674
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberSFI/13/ERC/B2775en
dc.contributor.sponsorGrantNumberSFI/13/CDA/2145en
dc.contributor.sponsorGrantNumberGOIPG/2014/515en
dc.contributor.sponsorGrantNumber637674en
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.subject.TCDTagARTERYen
dc.subject.TCDTagCOLLAGENen
dc.subject.TCDTagSmall angle light scatteringen
dc.subject.TCDTagstrain mediated degradationen
dc.status.accessibleNen


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