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dc.contributor.authorDunne, Aisling
dc.contributor.authorMahon, Olwyn R.
dc.date.accessioned2019-12-18T15:46:57Z
dc.date.available2019-12-18T15:46:57Z
dc.date.issued2018
dc.date.submitted2018en
dc.identifier.citationMahon, O.R. & Dunne, A., Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets, Frontiers in Immunology, 9, 2018en
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/91193
dc.descriptionPUBLISHEDen
dc.description.abstractIt is now well established that intra-articular deposition of endogenous particulates, such as osteoarthritis-associated basic calcium phosphate crystals, gout-associated monosodium urate crystals, and calcium deposition disease-associated calcium pyrophosphate crystals, contributes to joint destruction through the production of cartilage-degrading enzymes and pro-inflammatory cytokines. Furthermore, exogenous wear-debris particles, generated from prosthetic implants, drive periprosthetic osteolysis which impacts on the longevity of total joint replacements. Over the last few years, significant insight has been gained into the mechanisms through which these particulates exert their effects. Not only has this increased our understanding of the pathological processes associated with crystal deposition but it has also led to the identification of a number of therapeutic targets to treat particulate-associated disease. In this review, we discuss recent developments regarding the cellular events triggered by joint-associated particulates, as well as future directions in therapy for particulate-related arthropathies.en
dc.language.isoenen
dc.relation.ispartofseriesFrontiers in Immunology;
dc.relation.ispartofseries9;
dc.rightsYen
dc.subjectParticulatesen
dc.subjectOsteoarthritisen
dc.subjectGouten
dc.subjectCalcium deposition diseaseen
dc.subjectJoint inflammationen
dc.titleDisease associated particulates and joint inflammation; mechanistic insights and therapeutic targetsen
dc.typeReviewen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/aidunne
dc.identifier.rssinternalid193706
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeImmunology, Inflammation & Infectionen
dc.subject.TCDTagAutoimmune Diseases (Multiple Sclerosis, Rheumatoid Arthritis)en
dc.identifier.rssurihttps://www.frontiersin.org/articles/10.3389/fimmu.2018.01145/full
dc.subject.darat_impairmentChronic Health Conditionen
dc.subject.darat_thematicHealthen
dc.status.accessibleNen


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