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dc.contributor.authorSenge, Mathiasen
dc.date.accessioned2019-12-03T17:01:54Z
dc.date.available2019-12-03T17:01:54Z
dc.date.issued2018en
dc.date.submitted2018en
dc.identifier.citationCallaghan, S.; Senge, M. O., The good, the bad, and the ugly ? controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy., Photochemical & Photobiological Sciences, 17, 2018, 1490?1514.en
dc.identifier.otherYen
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2018/PP/C8PP00008E#!divAbstract
dc.identifier.urihttp://hdl.handle.net/2262/90959
dc.descriptionPUBLISHEDen
dc.description.abstractSinglet oxygen, although integral to photodynamic therapy, is notoriously uncontrollable, suffers from poor selectivity and has fast decomposition rates in biological media. Across the scientific community, there is a conscious effort to refine singlet oxygen interactions and initiate selective and controlled release to produce a consistent and reproducible therapeutic effect in target tissue. This perspective aims to provide an insight into the contemporary design principles behind photosensitizers and drug delivery systems that depend on a singlet oxygen response or controlled release. The discussion will be accompanied by in vitro and in vivo examples, in an attempt to highlight advancements in the field and future prospects for the more widespread application of photodynamic therapy.en
dc.format.extent1490?1514.en
dc.language.isoenen
dc.relation.ispartofseriesPhotochemical & Photobiological Sciencesen
dc.relation.ispartofseries17en
dc.rightsYen
dc.subjectPhotosensitizersen
dc.subjectSinglet oxygenen
dc.subjectPhotodynamic therapyen
dc.titleThe good, the bad, and the ugly ? controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy.en
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengemen
dc.identifier.rssinternalid195615en
dc.identifier.doihttp://dx.doi.org/10.1039/C8PP00008Een
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberIvP 13/ IA/1894en


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