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dc.contributor.authorMc Mahon, Barryen
dc.contributor.authorRegan, Julieen
dc.date.accessioned2019-11-20T12:43:01Z
dc.date.available2019-11-20T12:43:01Z
dc.date.issued2013en
dc.date.submitted2013en
dc.identifier.citationRegan J, Walshe M, Rommel N, Tack J, McMahon BP, New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP?., Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 25, 1, 2013, e25-34en
dc.identifier.otherYen
dc.identifier.urihttps://doi.org/10.1111/nmo.12041
dc.identifier.urihttp://hdl.handle.net/2262/90775
dc.descriptionPUBLISHEDen
dc.description.abstractBackground: This paper aims to measure upper esophageal sphincter (UES) distensibility and extent and duration of UES opening during swallowing in healthy subjects using EndoFLIP®. Methods: Fourteen healthy subjects (20–50 years) were recruited. An EndoFLIP® probe was passed trans‐orally and the probe balloon was positioned across the UES. Two 20‐mL ramp distensions were completed and UES cross‐sectional area (CSA) and intra‐balloon pressure (IBP) were evaluated. At 12‐mL balloon volume, subjects completed dry, 5‐ and 10‐mL liquid swallows and extent (mm) and duration (s) of UES opening and minimum IBP (mmHg) were analyzed across swallows. Key Results: Thirteen subjects completed the study protocol. A significant change in UES CSA (P < .001) and IBP (P < .000) was observed during 20‐mL distension. UES CSA increased up to 10‐mL distension (P < .001), from which point IBP raised significantly (P = 0.004). There were significant changes in UES diameter (mm) (P < .000) and minimum IBP (mmHg) (P < .000) during swallowing events. Resting UES diameter (4.9 mm; IQR 0.02) and minimum IBP (18.8 mmHg; IQR 2.64) changed significantly during dry (9.6 mm; IQR 1.3: P < .001) (3.6 mmHg; IQR 4.1: P = 0.002); 5 mL (8.61 mm; IQR 2.7: P < .001) (4.8 mmHg; IQR 5.7: P < .001) and 10‐mL swallows (8.3 mm; IQR 1.6: P < 0.001) (3 mmHg; 4.6: P < .001). Median duration of UES opening was 0.5 s across dry and liquid swallows (P = 0.91). Color contour plots of EndoFLIP® data capture novel information regarding pharyngo‐esophageal events during swallowing. Conclusions & Inferences: Authors obtained three different types of quantitative data (CSA, IBP, and timing) regarding UES distensibility and UES opening patterns during swallowing in healthy adults using only one device (EndoFLIP®). This new measure of swallowing offers fresh information regarding UES dynamics which may ultimately improve patient care.en
dc.format.extente25-34en
dc.language.isoenen
dc.relation.ispartofseriesNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Societyen
dc.relation.ispartofseries25en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectDeglutitionen
dc.subjectDysphagiaen
dc.subjectEvaluationen
dc.subjectFLIPen
dc.subjectSwallowingen
dc.subjectUpper esophageal sphincteren
dc.titleNew measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP?.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mcmahoben
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jureganen
dc.identifier.rssinternalid100388en
dc.identifier.doihttps://doi.org/10.1111/nmo.12041en
dc.rights.ecaccessrightsopenAccess
dc.subject.TCDThemeNext Generation Medical Devicesen
dc.subject.TCDTagDYSPHAGIAen
dc.identifier.orcid_id0000-0002-0474-6710en


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