The role of novel IL-1 family members in Inflammatory Bowel Disease
Citation:Rachel M. Horan, 'The role of novel IL-1 family members in Inflammatory Bowel Disease', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015, pp 176
Horan TCD THESIS 11255 The role.pdf (PDF) 64.45Mb
Inflammatory Bowel Disease (IBD) is characterized by an imbalance between effector and regulatory arms of intestinal immunity. Emerging evidence suggests that IL-1 family members play a critical role in the maintenance of gut homeostasis. In this study we have measured expression levels of the novel IL-1 family members, IL-36 and IL-37, in a paediatric IBD cohort. We subsequently used the DSS model of colitis to investigate the role of the IL-36R pathway in intestinal inflammation.
Author: Horan, Rachel M.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine
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Type of material:thesis
Availability:Full text available