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dc.contributor.advisorO'Neill, Luke
dc.contributor.authorHennessy, Elizabeth J.
dc.date.accessioned2019-11-06T15:46:21Z
dc.date.available2019-11-06T15:46:21Z
dc.date.issued2010
dc.identifier.citationElizabeth J. Hennessy, 'The role of microRNA-107 in Toll-like receptor signaling', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010, pp 271
dc.identifier.otherTHESIS 9438
dc.identifier.urihttp://hdl.handle.net/2262/90220
dc.description.abstractMicroRNAs (miRNAs) are a novel class of small non-coding RNA regulatory molecules which post-transcriptionally regulate genes in a fine-tuning manner. Multiple miRNAs have been shown to be regulated by Toll-like receptors (TLRs), including miR-146a, miR-155 and miR-21. In this study, I have found that the TLR4 ligand lipopolysaccharide (LPS) can down-regulate microRNA-107 (miR- 107). miR-107 is downregulated in response to LPS in many cell lines as well as in primary mouse and human cells.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Biochemistry and Immunology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14881944
dc.subjectBiochemistry, Ph.D.
dc.subjectPh.D. Trinity College Dublin.
dc.titleThe role of microRNA-107 in Toll-like receptor signaling
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 271
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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