dc.contributor.advisor | O'Neill, Luke | |
dc.contributor.author | Hennessy, Elizabeth J. | |
dc.date.accessioned | 2019-11-06T15:46:21Z | |
dc.date.available | 2019-11-06T15:46:21Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Elizabeth J. Hennessy, 'The role of microRNA-107 in Toll-like receptor signaling', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2010, pp 271 | |
dc.identifier.other | THESIS 9438 | |
dc.identifier.uri | http://hdl.handle.net/2262/90220 | |
dc.description.abstract | MicroRNAs (miRNAs) are a novel class of small non-coding RNA regulatory
molecules which post-transcriptionally regulate genes in a fine-tuning manner.
Multiple miRNAs have been shown to be regulated by Toll-like receptors (TLRs),
including miR-146a, miR-155 and miR-21. In this study, I have found that the
TLR4 ligand lipopolysaccharide (LPS) can down-regulate microRNA-107 (miR-
107). miR-107 is downregulated in response to LPS in many cell lines as well as
in primary mouse and human cells. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). School of Biochemistry and Immunology | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14881944 | |
dc.subject | Biochemistry, Ph.D. | |
dc.subject | Ph.D. Trinity College Dublin. | |
dc.title | The role of microRNA-107 in Toll-like receptor signaling | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Doctoral | |
dc.type.qualificationname | Doctor of Philosophy (Ph.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 271 | |
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