Show simple item record

dc.contributor.advisorBowie, Andrew
dc.contributor.authorGürtler, Claudia
dc.date.accessioned2019-11-06T14:44:08Z
dc.date.available2019-11-06T14:44:08Z
dc.date.issued2012
dc.identifier.citationClaudia Gürtler, 'Exploring an immune function for murine SARM', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012, pp 235
dc.identifier.otherTHESIS 9807
dc.identifier.urihttp://hdl.handle.net/2262/90201
dc.description.abstractInnate immune cells, such as tissue-residing macrophages and dendritic cells (DCs) play a key role in initiating an immune response following the detection of invading pathogens via germline-encoded pattern-recognition receptors (PRRs) present on the cell surface or in intracellular compartments and the cytosol. PRRs selectively recognise conserved molecular features of the microbe and subsequently initiate distinct signalling cascades leading to transcription factor activation and the induction of proinflammatory cytokines (e.g. TNF-a), chemokines (e.g. CCL5/RANTES) and type I interferons (i.e. IFNa and IFN-β). One major family of PRRs are the membrane-bound Toll-like receptors (TLRs), which signal via the Toll/IL-1 receptor (TIR) domain-containing adaptor proteins IVIyD88, MAL, TRIP and TRAM. The immunological function of the fifth most evolutionarily conserved TIR adaptor sterile alpha and HEAT/Armadillo motif protein (SARM) is still enigmatic.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Biochemistry and Immunology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15318278
dc.subjectBiochemistry & Immunology, Ph.D.
dc.subjectPh.D. Trinity College Dublin.
dc.titleExploring an immune function for murine SARM
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 235
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record