Exploring the bases of hippocampal- and prefrontal-based memory : the effect of age and disease
Citation:
Gillian Cooke, 'Exploring the bases of hippocampal- and prefrontal-based memory : the effect of age and disease', [thesis], Trinity College (Dublin, Ireland). School of Psychology, 2010, pp 312Download Item:
Cooke TCD THESIS 8979 Exploring the.pdf (PDF) 135.2Mb
Abstract:
Memory formation largely depends on normal function of the temporal lobes (particularly the
hippocampal complex) and the prefrontal cortex. The relationship between these two regions
and the degree to which each region is engaged during different memory tasks is still unclear.
Evidence from animal studies suggests abnormal hippocampal functioning in hypothyroidism
(Alzoubi, Gerges, & Alkadhi, 2005), and abnormal prefrontal functioning in aging (Allain et
al., 2005). This study investigates the nature of the relationship between memory tasks that
have been associated with hippocampal and prefrontal cortex (PFC) regions, and examines
how this relationship changes when either region is damaged; the hippocampus as a result of
hypothyroidism, and the prefrontal cortex as a result of aging. It is hypothesised that specific
defects in memory tasks associated with the hippocampus will be observed in hypothyroid
patients, while specific deficits in memory tasks associated with both prefrontal- and
hippocampal regions will be observed in healthy older adults.
Author: Cooke, Gillian
Advisor:
O'Mara, ShaneQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of PsychologyNote:
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Psychology, Ph.D., Ph.D. Trinity College Dublin.Licences: