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dc.contributor.authorBrowne, Paul
dc.contributor.authorSahebi, Firoozeh
dc.contributor.authorIacobelli, Simona
dc.contributor.authorSbianchi, Giulia
dc.contributor.authorKoster, Linda
dc.contributor.authorBlaise, Didier
dc.contributor.authorReményi, Péter
dc.contributor.authorRussell, Nigel H.
dc.contributor.authorLjungman, Per
dc.contributor.authorKobbe, Guido
dc.contributor.authorApperley, Jane
dc.contributor.authorTrneny, Marek
dc.contributor.authorKrejci, Marta
dc.contributor.authorWiktor-Jedrzejczak, Wieslaw
dc.contributor.authorSanchez, James F.
dc.contributor.authorSchaap, Nicolaas
dc.contributor.authorIsaakson, Cecilia
dc.contributor.authorLenhoff, Stig
dc.contributor.authorScheid, Christof
dc.contributor.authorWilson, Keith M.O.
dc.contributor.authorYakoub-Agha, Ibrahim
dc.contributor.authorGonzález Muñiz, Soledad
dc.contributor.authorSchönland, Stefan
dc.contributor.authorMorris, Curly
dc.contributor.authorGarderet, Laurent
dc.contributor.authorKröger, Nicolaus
dc.date.accessioned2019-10-29T15:35:46Z
dc.date.available2019-10-29T15:35:46Z
dc.date.issued2018
dc.date.submitted2018en
dc.identifier.citationSahebi, F., Iacobelli, S., Sbianchi, G., Koster, L., Blaise, D. , Reményi, P., Russell, N.H., Ljungman, P., Kobbe, G., Apperley, J., Trneny, M., Krejci, M., Wiktor-Jedrzejczak, W., Sanchez, J.F., Schaap, N., Isaksson, C., Lenhoff, S., Browne, P., Scheid, C., Wilson, K.M.O., Yakoub-Agha, I., Muñiz, S.G. and Schönland, S., Morris, C., Garderet, L. & Kröger, N. Incidence of Second Primary Malignancies after Autologous Transplantation for Multiple Myeloma in the Era of Novel Agents, Biology of Blood and Marrow Transplantation, 24, 5, 2018, 930-936en
dc.identifier.otherY
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1083879118300211?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/2262/89935
dc.description.abstractThe advent of novel agents for multiple myeloma (MM) is cause for a re-examination of the incidence of second primary malignancies (SPMs). We examined the SPM rate in MM patients who were enrolled in the prospective observational CALM (Collaboration to Collect Autologous Transplant outcome in Lymphoma and Myeloma) study. Between 2008 and 2012, 3204 patients with MM underwent a first autologous hematopoietic stem cell transplantation. Plerixafor was used as a mobilizing agent for patients with poor (or potentially poor) stem cell mobilization as defined by the respective centers. A total of 135 patients developed SPMs, with a cumulative incidence of 5.3% (95% confidence interval, 4.4 to 6.3) at 72 months. Ninety-four patients developed solid tumors, 30 developed hematologic malignancies, and 11 developed an SPM of an unknown type. The cumulative incidence of known hematologic and solid malignancies were 1.4% and 3.6%, respectively, at 72 months. In a univariate analysis, use of radiotherapy, type of induction regimen, hematopoietic stem cell dose, poor mobilizer status, plerixafor use, and sex did not influence the cumulative incidence of SPMs. Only age over 65 years was statistically associated with an increased incidence. Overall, the incidence of SPMs was comparable to earlier estimations of SPMs in MM.en
dc.format.extent930-936en
dc.language.isoenen
dc.relation.ispartofseriesBiology of Blood and Marrow Transplantation;
dc.relation.ispartofseries24;
dc.relation.ispartofseries5;
dc.rightsYen
dc.subjectMultiple myeloma (MM)en
dc.subjectSecond primary malignanciesen
dc.subjectImmunomodulatory drugsen
dc.subjectProteasome inhibitorsen
dc.subjectPlerixaforen
dc.titleIncidence of Second Primary Malignancies after Autologous Transplantation for Multiple Myeloma in the Era of Novel Agentsen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/brownpv
dc.identifier.rssinternalid188908
dc.identifier.doihttp://dx.doi.org/10.1016/j.bbmt.2018.01.006
dc.rights.ecaccessrightsopenAccess
dc.identifier.orcid_id0000-0001-5310-1487


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