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dc.contributor.authorRowan, Michael
dc.contributor.authorO'Riordan, Kenneth J.
dc.contributor.authorHu, Neng-Wei
dc.date.accessioned2019-10-25T12:25:45Z
dc.date.available2019-10-25T12:25:45Z
dc.date.issued2018
dc.date.submitted2018en
dc.identifier.citationO'Riordan, K.J., Hu, N. & Rowan, M.J. Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus, 2018, Cell Reports, 22, 8en
dc.identifier.otherY
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2211124718301499?via%3Dihub
dc.identifier.urihttp://hdl.handle.net/2262/89893
dc.description.abstractPromotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively non-specific electrical stimulation. Exploiting optogenetics, we studied LTD using a more physiologically diffuse spatial pattern of selective pathway activation in the rat hippocampus in vivo. This relatively sparse synaptic LTD requires both the ion channel function and GluN2B subunit of the NMDA receptor but, in contrast to electrically induced LTD, is not facilitated by boosting endogenous muscarinic acetylcholine or metabotropic glutamate 5 receptor activation. Although in the absence of Aß, there is no evidence of hippocampal LTD asymmetry, in the presence of Aß, the induction of LTD is preferentially enhanced in the left hippocampus in an mGluR5-dependent manner. This circuit-selective disruption of synaptic plasticity by Aß provides a route to understanding the development of aberrant brain lateralization in AD.en
dc.format.extent2094-2106en
dc.language.isoenen
dc.relation.ispartofseriesCell Reports;
dc.relation.ispartofseries22;
dc.relation.ispartofseries8;
dc.rightsYen
dc.subjectSynaptic plasticityen
dc.subjectAlzheimer's diseaseen
dc.subjectLong-term depression (LTD)en
dc.subjectCortical asymmetryen
dc.subjectBrain lateralizationen
dc.subjectAmyloid-β proteinen
dc.subjectN-methyl-D-aspartate receptoren
dc.subjectGluN2B subuniten
dc.subjectMetabotropic glutamate 5 receptoren
dc.subjectMuscarinic acetylcholine receptoren
dc.subject.lcshlong-term depression (LTD)en
dc.titleAß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampusen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Irelanden
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mrowan
dc.identifier.rssinternalid191419
dc.identifier.doihttp://dx.doi.org/10.1016/j.celrep.2018.01.085
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber14/IA/2571en


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