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dc.contributor.authorBokde, Arun
dc.contributor.authorWhelan, Robert
dc.date.accessioned2019-09-17T14:24:38Z
dc.date.available2019-09-17T14:24:38Z
dc.date.issued2019
dc.date.submitted2019en
dc.identifier.citationCao Z, Bennett M, Orr C, Icke I, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Buchel C, Quinlan EB, Desrivieres S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Frohner JH, Smolka MN, Walter H, Schumann G, Whelan R, IMAGEN Consortium., Mapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task. Human brain mapping, 2019, 40, 1, 262-283en
dc.identifier.issn1065-9471
dc.identifier.otherY
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/hbm.24370
dc.identifier.urihttp://hdl.handle.net/2262/89510
dc.descriptionPUBLISHEDen
dc.description.abstractThe functional neuroanatomy and connectivity of reward processing in adults are well documented, with relatively less research on adolescents, a notable gap given this developmental period’s association with altered reward sensitivity. Here, a large sample (n= 1,510) of adolescents per-formed the monetary incentive delay (MID) task during functional magnetic resonance imaging.Probabilistic maps identified brain regions that were reliably responsive to reward anticipation and receipt, and to prediction errors derived from a computational model. Psychophysiological interactions analyses were used to examine functional connections throughout reward processing. Bilateral ventral striatum, pallidum, insula, thalamus, hippocampus, cingulate cortex, midbrain, motor area, and occipital areas were reliably activated during reward anticipation.Bilateral ventromedial prefrontal cortex and bilateral thalamus exhibited positive and negative activation, respectively, during reward receipt. Bilateral ventral striatum was reliably active following prediction errors. Previously, individual differences in the personality trait of sensation seeking were shown to be related to individual differences in sensitivity to reward outcome. Here, we found that sensation seeking scores were negatively correlated with right inferior frontal gyrus activity following reward prediction errors estimated using a computational model. Psychophysiological interactions demonstrated widespread cortical and subcortical connectivity during reward processing, including connectivity between reward-related regions with motor areas and the salience network. Males had more activation in left putamen, right precuneus, and middle temporal gyrus during reward anticipation. In summary, we found that, in adolescents,different reward processing stages during the MID task were robustly associated with distinctive patterns of activation and of connectivity.en
dc.format.extent262-283en
dc.language.isoenen
dc.relation.ispartofseriesHuman brain mapping;
dc.relation.ispartofseries40;
dc.relation.ispartofseries1;
dc.rightsYen
dc.subjectFunctional connectivityen
dc.subjectGender differencesen
dc.subjectReward processingen
dc.subjectSensation seekingen
dc.subjectAdolescenceen
dc.titleMapping adolescent reward anticipation, receipt, and prediction error during the monetary incentive delay task.en
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/whelanr3
dc.identifier.peoplefinderurlhttp://people.tcd.ie/bokdea
dc.identifier.rssinternalid196090
dc.identifier.doihttp://dx.doi.org/10.1002/hbm.24370
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumber16/ ERCD/3797en
dc.identifier.orcid_id0000-0002-2790-7281


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