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dc.contributor.authorSenge, Mathiasen
dc.date.accessioned2019-08-28T12:27:35Z
dc.date.available2019-08-28T12:27:35Z
dc.date.issued2018en
dc.date.submitted2018en
dc.identifier.citationLocke Gemma M, Bernhard Stefan S R, Senge Mathias O, Nonconjugated Hydrocarbons as Rigid-Linear Motifs: Isosteres for Material Sciences and Bioorganic and Medicinal Chemistry, Chemistry (Weinheim an der Bergstrasse, Germany), 2018, 4590 ?4647en
dc.identifier.issn0947-6539en
dc.identifier.otherYen
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/full/10.1002/chem.201804225
dc.identifier.urihttp://hdl.handle.net/2262/89368
dc.descriptionPUBLISHEDen
dc.description.abstractNonconjugated hydrocarbons, like bicyclo[1.1.1]pentane, bicyclo[2.2.2]octane, triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and shape they are useful mimics of classic benzene moieties in drugs, so-called bioisosteres. Moreover, they also fulfill an important role in material sciences as linear linkers, in order to arrange various functionalities in a defined spatial manner. In this Review article, recent developments and usages of these special, rectilinear systems are discussed. Furthermore, we focus on covalently linked, nonconjugated linear arrangements and discuss the physical and chemical properties and differences of individual linkers, as well as their application in material and medicinal sciences.en
dc.format.extent4590 ?4647en
dc.language.isoenen
dc.relation.ispartofseriesChemistry (Weinheim an der Bergstrasse, Germany)en
dc.rightsYen
dc.subjectBioisosteresen
dc.subjectNonconjugated hydrocarbonsen
dc.subjectRectilinear systemsen
dc.subjectNonconjugated linear arrangementsen
dc.subjectIndividual linkersen
dc.subjectMaterial sciencesen
dc.subjectMedicinal sciencesen
dc.titleNonconjugated Hydrocarbons as Rigid-Linear Motifs: Isosteres for Material Sciences and Bioorganic and Medicinal Chemistryen
dc.typeJournal Articleen
dc.contributor.sponsorScience Foundation Ireland (SFI)en
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/sengemen
dc.identifier.rssinternalid195772en
dc.identifier.doihttp://dx.doi.org/10.1002/chem.201804225en
dc.rights.ecaccessrightsopenAccess
dc.contributor.sponsorGrantNumberIvP 13/IA/1894en
dc.identifier.rssurihttp://europepmc.org/abstract/MED/30387906 https://doi.org/10.1002/chem.201804225en


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