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dc.contributor.advisorAtkins, Greg
dc.contributor.authorSmyth, James William Peter
dc.date.accessioned2019-07-30T14:35:48Z
dc.date.available2019-07-30T14:35:48Z
dc.date.issued2005
dc.identifier.citationJames William Peter Smyth, 'Inhibition of K-BALB murine tumours using Semliki Forest virus and its derived factor', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology, 2005, pp 248
dc.identifier.otherTHESIS 7408
dc.identifier.urihttp://hdl.handle.net/2262/89094
dc.description.abstractThe induction of cytopathic effects in tumour cells, often by apoptosis, is the primary goal of most non-surgical cancer therapies. Cancer gene therapy represents a variety of potentially therapeutic strategies involving the introduction of new genetic information into cells with the aim of abrogating tumourigenicity or eliciting therapeutic effects. A large proportion of cancer gene therapy research is devoted to immunotherapy, which involves the induction or potentiation of host antitumour immune responses. Antigens associated with tumourigenesis have been identified and exploited in this field, but given the unstable nature of tum our cell phenotype and antigen expression, these strategies may be of limited value. Rather than restricting therapy to a specific antigen, the expression of Semliki Forest virus (SFV) antigens (predominantly E2) is employed in this study with the aim of inducing host immune responses against infected tum our cells.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Microbiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12411951
dc.subjectMicrobiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleInhibition of K-BALB murine tumours using Semliki Forest virus and its derived factor
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 248
dc.description.noteTARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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