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dc.contributor.advisorLee, Clive
dc.contributor.advisorCroke, D.T.
dc.contributor.authorHardiman, David A.
dc.date.accessioned2019-07-25T11:07:49Z
dc.date.available2019-07-25T11:07:49Z
dc.date.issued2004
dc.identifier.citationDavid A. Hardiman, 'Adaptation of growing bone to altered mechanical load : morphological change, structural strength and gene expression', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004, pp 274
dc.identifier.otherTHESIS 7490
dc.identifier.urihttp://hdl.handle.net/2262/88874
dc.description.abstractOsteoporosis, a condition characterised by a loss of bone mass, is of increasing clinical interest in an aging population. Bone formation and growth are controlled by genetic, hormonal and biomechanical factors. This multifactorial regulation is present in utero with mechanical loading critical in regulating skeletogenesis. After birth, growth and ossification are strongly influenced by physical activity and externally applied forces. Clinically, reduced loading may occur due to bed-rest, paralysis or stress shielding around implants while overloading may lead to differential growth and skeletal asymmetry.
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb12426447
dc.subjectMechanical and Manufacturing Engineering, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleAdaptation of growing bone to altered mechanical load : morphological change, structural strength and gene expression
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 274
dc.description.noteTARA (Trinity's Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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