A study of anionic drug transport processes governing passive and enhanced transdermal delivery

Abstract

The research contained herein is directed at defining some of the factors which govern the passive and enhanced transdermal transport of anionic drugs and will extend current knowledge which largely pertains to the analogous behaviour of cationic drugs. Measurements have been made of the release profiles of anionic drugs from liquid crystalline gels across artificial and human stratum corneum membranes. The effects of the addition of surfactants and fatty acid chemical penetration enhancers, and of the use of electrical assistance and also the synergistic effects of the similtaneous application of both methods to increase drug transport have also been studied.