Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 359-378 of 587
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N-subsituted homopiperazine barbiturates as gelatinase inhibitors
(2011)Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5,5-Disubstituted barbiturates hold promise as ... -
N1-dansyl-spermine: a potent polyamine antagonist.
(2004)The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2?10 ?g, i.c.v.) with spermine ... -
Nanoparticles attenuate P-glycoprotein/MDR1 function in A549 human alveolar epithelial cells
(2011)P-glycoprotein/MDR1 (P-gp) is a well characterised membrane transporter relevant in drug disposition and multi-drug resistance. In this study, we aimed to investigate in how far nanoparticulates impair the function of the ... -
Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia.
(2013)The oil of babassu tree nuts (Orbignya speciosa) is a potential alternative for treatment and prophylaxis of benign prostatic hyperplasia. Improved results can be obtained by drug vectorization to the hyperplastic tissue. ... -
Neratinib-resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4
(2017)Background: Neratinib is in Phase 3 clinical trials but, unfortunately, the development of resistance is inevitable. Here, we investigated the effects of acquired neratinib resistance on cellular phenotype and the ... -
Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer
(2017)Neuromedin U (NmU) is a neuropeptide belonging to the neuromedin family. Recently, we reported a significant association between NmU and breast cancer, particularly correlating with increased aggressiveness, resistance to ... -
Neuronal Nitric oxide synthase : a novel target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Major depressive disorder (MDD) is one of the most common psychiatric disorders and its origin has been attributed to dysfunction of the monoamine systems, particularly noradrenergic and serotonergic, making them the main ... -
New solid forms of itraconazole and their pharmaceutical applications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Itraconazole (ITR) is an active pharmaceutical ingredient (API) with a broad-spectrum antifungal activity. This API has a very low solubility, which can hinder its bioavailability after oral administration. In this work, ... -
Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Inflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed ... -
Non-Prescription Medicinal Products containing codeine: guidance for pharmacists on safe supply to patients
(Pharmaceutical Society of Ireland, 2010) -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase
(2008)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ... -
Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics for Alzheimer's Disease
(2016)sosorbide-2-carbamates-5-aryl esters are highly potent and very selective butyrylcholinesterase inhibitors. The objective of the present work was to address the hypothesis that the isosorbide-aryl-5-ester group could be ... -
A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): identification, synthesis and antinociceptive activity
(2012)2-Pentylpiperidine, named conmaculatin, a novel volatile alkaloid related to coniine was identified from the renowned toxic weed Conium maculatum L. (Apiaceae). The structure of conmaculatin was corroborated by synthesis ...
