Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 78-97 of 580
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Characterisation of drug-fatty acid composites and their use in drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Fatty acids are considered to be useful as carrier materials in the formulation of drug delivery systems. Literature on fatty acid systems, in particular, stearic acid, was reviewed, though in general, research in this ... -
Characterisation of polymorphisms on the promoter region of the human histamine 4 receptor
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The human histamine 4 receptor (HRH4) is the recently discovered receptor in the histamine GPCR family. It is mainly expressed in haematopoietic cells but recent publications provide evidence that it is both expressed and ... -
Characterisation of the functional role of OCTN1 in the pathogenesis of COPD
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The organic cation transporter (OCTN1) has been reported to play a role in the pathogenesis and development of inflammatory diseases. However, this association remains conflicting. Without fully elucidating the physiological ... -
Characterisation, solubility and intrinsic dissolution behaviour of benzamide:dibenzyl sulfoxide cocrystal
(2012)This study examined the 1:1 cocrystal benzamide:dibenzyl sulfoxide, comprising the poorly water soluble dibenzyl sulfoxide (DBSO) and the more soluble benzamide (BA), to establish if this cocrystal shows advantages in terms ... -
Chemical biology studies on human and mouse secondary bile acids
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Bile acids are important regulators of multiple homeostatic mechanisms integrating cell proliferation, metabolism and inflammation. The overall objective of this thesis was to use chemical biology tools to understand ... -
Chemical composition and enzyme inhibition of Phytolacca dioica L. seeds extracts
(2019)Phytolacca, which belongs to the family of Phytolaccaceae, are known for their use in popular medicine.Bioactivity of five extracts from Phytolacca dioica seeds were evaluated in four bioassays. A selected groupof compounds ... -
Chemistry and Biology studies on anti-inflammiatory bile acid derivatives
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Abstract The objective of the dissertation is to clarify the potency, cytotoxicity and metabolism of novel steroidal anti-inflammatory compounds in the treatment inflammatory bowel disease (IBD). Biochemical methods with ... -
Chemistry and pharmacology of the kazakh crataegus almaatensis pojark: An asian herbal medicine
(2019)Crataegus almaatensis, an endemic ornamental plant in Kazakhstan is used in popular medicine due to its cardiotonic properties. The most studied species of the same genus are commonly found in Europe, which shows the ... -
Co-spray dried carbohydrate microparticles: crystallisation delay/inhibition and improved aerosolization characteristics through the incorporation of hydroxypropyl-?-cyclodextrin with amorphous raffinose or trehalose
(2015)PURPOSE: To formulate and investigate the physicochemical properties, physical stability and aerosolization characteristics of nanoporous/nanoparticulate microparticles (NPMPs) prepared by co-spray drying the sugars ... -
Cocrystal habit engineering to improve drug dissolution and alter derived powder properties
(2016)Objectives: Cocrystallization of sulfadimidine (SDM) with suitable coformers, such as 4-aminosalicylic acid (4-ASA), combined with changes in the crystal habit can favourably alter its physicochemical properties. The aim ... -
Collaborative pharmaceutical care in an Irish hospital: uncontrolled before-after study
(2014)Background We investigated the benefits of the Collaborative Pharmaceutical Care in Tallaght Hospital (PACT) service versus standard ward-based clinical pharmacy in adult inpatients receiving acute medical care, particularly ... -
Comparative evaluation of rivastigmine permeation from a transdermal system in the Franz cell using synthetic membranes and pig ear skin with in vivo-in vitro correlation
(2016)In the present study, in vitro permeation experiments in a Franz diffusion cell were performed using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine (RV) transdermal drug delivery system. ... -
A comparative study between hot-melt extrusion and spray-drying for the manufacture of anti-hypertension compatible monolithic fixed-dose combination products.
(2018)The purpose of this work was to investigate the application of different advanced continuous processing techniques (hot melt extrusion and spray drying) to the production of fixed-dose combination (FDC) monolithic systems ... -
A comparison of community pharmacy methadone services between Dublin and Glasgow: (1) Extent of service provision in 1997/8 and views of pharmacists on existing provision and future service developments.
(2004)Objectives: To determine the extent of pharmacists' participation in methadone services, type of services provided, views on current service provision and suggestions for future service developments. Methods and setting: ... -
Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways
(2018)Sample complexity and polydispersity presents challenges surrounding particle size measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the marketplace it is imperative that this task ...
