Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 539-558 of 567
-
Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells
(2015)Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide for a variety of engineering and bioengineering applications. TiO2NPs are frequently used as a material for orthopedic implants. However, to the best ... -
Traditional Chinese Medicine: From Aqueous Extracts to Therapeutic Formulae
(IntechOpen, 2019)Traditional Chinese medicine (TCM) is one of the most established systems of medicine in the world. The therapeutic formulae used in TCM are frequently derived from aqueous decoctions of single plants or complex multicomponent ... -
Traditional Medicinal Knowledge documented in the Schools Manuscript Collection: An insight into the medical beliefs, practices and healing plants used in 1930s Ireland.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)The National Folklore Collection (NFC) in University College Dublin holds one of the largest collections of ethnographic material globally. In 2017, the Irish Folklore Commission Collection (1935-1970), housed within the ... -
Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells
(2012)Organic cation/carnitine transporters (OCT/N) mediate uptake of positively charged molecules. Their role in lung epithelium, however, is not well understood. OCT/N expression and activity was studied in cell lines of human ... -
Triple negative breast cancer-derived extracellular-vesicles as naturally-occuring biomarkers and therapeutic delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Background: In Ireland, breast cancer is the most commonly diagnosed cancer among women; and of the breast cancer subtypes, triple-negative breast cancers (TNBC) are the most aggressive. TNBCs account for 15%-20% of breast ... -
Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism
(2012)Peroxisome proliferator activated receptor ? (PPAR?) agonists are effective antifibrotic agents in a number of tissues. Effects of these agents on epithelial-mesenchymal transition (EMT) of primary alveolar epithelial cells ... -
Tumour microenvironment, extracellular vesicles and their effect on prostate cancer progression and docetaxel resistance
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Prostate cancer is the fourth most common cancer in Europe and the third leading cause of death in males. The standard of care as initial treatment for prostate cancer is, typically, androgen-deprivation therapy. Although ... -
Tumour vasculature targeting agents in hybrid/conjugate drugs.
(2013)Tumour vasculature targeting has been a very active area of cancer drug discovery over the last decade. Growth of solid tumours beyond a certain point requires a sufficient blood supply in order for them to develop and ... -
Twenty-first century mast cell stabilizers
(2013)Mast cell stabilizing drugs inhibit the release of allergic mediators from mast cells and are used clinically to prevent allergic reactions to common allergens. Despite the relative success of the most commonly prescribed ... -
Understanding the Carbon-Bio Interface: Influence of Surface Chemistry and Buffer Composition on the Adsorption of Phospholipid Liposomes at Carbon Surfaces
(2020)Surface active phospholipids are present in fluids of biological relevance, and their adsorption may condition and determine the response of carbon and nanocarbon surfaces when they are immersed in physiological media. In ... -
Understanding the role of low glass transition temperature excipients in the mitigation of amorphisation on mechanical processing
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Commonly employed pharmaceutical processes such as milling, blending and compaction may unintentionally lead to the generation of amorphous regions or metastable polymorphic forms in crystalline active pharmaceutical ... -
Unintended discontinuation of medication following hospitalisation: a retrospective cohort study
(BMJ Publishing Group, 2019)Objectives: Whether unintended discontinuation of common, evidence-based, long-term medication occurs after hospitalisation; what factors are associated with unintended discontinuation; and whether the presence of documentation ... -
A Unique Polysaccharide containing 3-O-Methylarabinose and 3-O-Methylgalactose from Tinospora sinensis
(2018)Tinospora sinensis (Lour.) Merrill is of great therapeutic significance in Indian traditional medicine. Crude polysaccharides were isolated from methanol pre-extracted stems of dried material by successive extractions with ... -
Updating MISEV: Evolving the minimal requirements for studies of extracellular vesicles
(2021)The minimal information for studies of extracellular vesicles (EVs, MISEV) is a field-consensus rigour initiative of the International Society for Extracellular Vesicles (ISEV). The last update to MISEV, MISEV2018, was ... -
Upgrading Methylation Method for Structural Studies of Polysaccharides: Case Analysis of a Bioactive Polysaccharide from Acacia tortilis.
(2020)Methylation has been the most widely used conventional tool in the structural characterization of polysaccharides. In the series of developments in methylation methods employing a diverse range of solvents and methylating ... -
Use of computational fluid dynamics to investigate the relationship between hydrodynamics and rates of dissolution
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The hydrodynamics within the paddle (900 ml), basket (900 ml) and Levy beaker (350 ml and 550 ml) (Levy et al., 1965) dissolution apparatuses were simulated using the computational fluid dynamics (CFD) package, Fluent™. ...
