Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 523-542 of 567
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The design, implementation, and evaluation of a medication safety programme in an acute Irish teaching hospital
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The research undertaken for this thesis aimed to address the current deficit which exists in relation to the status of medication safety in Irish hospitals and add to the limited body of published data available from any ... -
The design, synthesis and biological effects of novel steroid prodrugs for treatment of gastrointestinal diseases
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The aim of the work described in this thesis was to synthesize and test the biological effects of a novel type of prodrug to deliver steroids to the colon for the treatment of gastrointestinal diseases. Glucocorticoids are ... -
The design, synthesis and biological evaluation of novel multiple targeting anti-cancer agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The purpose of the work undertaken within this project was to design and synthesis novel anti-cancer targeting compounds building upon previous work undertaken under the supervision of Dr. John J. Walsh in the School of ... -
The design, synthesis and preliminary evaluation of prodrugs and hybrid drugs with tubulin polymerisation inhibitory activity and anti-proliferative activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The objective of this project was to design, synthesise and carry out preliminary evaluations on potential prodrugs and hybrid drugs with anti-proliferative effects. Chapter 1 gives an overview of current trends in cancer ... -
The development, validation and application of analytical methods for the analysis of drugs of abuse
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)There are five chapters presented in this thesis. The first chapter deals with development and validation of a HPLC method for the analysis of MDMA in illicitly produced Ecstasy tablets. In all 100 tablets were analysed ... -
The effect of processing on the solid state characteristis of selected sulphonamides and their sodium salts, alone and as drug-salt composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The purpose of the research presented in this thesis was to produce metastable active pharmaceutical ingredients (API) by spray drying and to analyse, physico-chemically characterise these forms and develop strategies to ... -
The influence of drug physicochemical properties on release from thermoresponsive smart hydrogels
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Thermoresponsive hydrogels are a class of "smart" or "environmentally sensitive" systems with potential for controlling the release of a drug in response to a specific stimulus. Previous research in the area of thermoresponsive ... -
The optimisation, characterisation and platelet compatibility of polymeric nanocarriers loaded with NSAIDs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)There is a constant drive towards improving global health by continuously enhancing the quality of drugs available and the systems to deliver these drugs efficiently in order to treat disease. This thesis focused on the ... -
The pharmacological and toxicological effects of polystyrene and silica nanoparticles on human airway epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: A number of lung pathologies are associated with the dysfunction of ion flux through pulmonary epithelium. Cystic fibrosis (CF) is a chronic and life-threatening genetic disease that directly affects ... -
The pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)This study sought to determine the pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors (BuChEl’s) in vitro and in vivo. The potency of the novel compounds 2-benzylcarbamate 5-nicotinate ... -
The production and characterisation of spray dried nanoporous microparticles (NPMPs) intended for dry powder inhalation drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The focus of the research presented in this thesis was on the potential application of a novel spray drying method to produce excipient-free nanoporous microparticles (NPMPs) of bioactive drug compounds and co-spray dried ... -
The role of the community pharmacist in optimising patients' inhaler use in asthma management
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The Asthma Insights and Reality in Ireland survey revealed that only 8% of those surveyed had controlled asthma, as defined by evidence-based guidelines. A detailed analysis of patients’ abilities to use their inhalation ... -
The specialist pharmacist and quality indicators of medication use in the care of people with intellectual disabilities and behaviour disorders
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)Quality Medication Use and the Population with Intellectual Disabilities and Behaviour Disorders. A Modified Delphi Technique to develop Quality Indicators and a Grounded Theory approach to information provided by people ... -
The synthesis and biological evaluation of a novel class of butyrylcholinesterase inhibitors using isosorbide as a building block
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this project was to synthesise and optimise a novel class of cholinesterase inhibitors using the simple sugar, isosorbide, as a building block and to assess the inhibitory activity of these compounds in vitro. ... -
The synthesis of novel mast cell stabilisers from benzocycloalkanones
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)The purpose of this project was to design and synthesise novel classes of mast cell stabilisers from benzocycloalkanones. This thesis is introduced with an overview of the increasing prevalence of allergic conditions ... -
Titanium dioxide nanoparticles enhance production of superoxide anion and alter the antioxidant system in human osteoblast cells
(2015)Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide for a variety of engineering and bioengineering applications. TiO2NPs are frequently used as a material for orthopedic implants. However, to the best ... -
Traditional Chinese Medicine: From Aqueous Extracts to Therapeutic Formulae
(IntechOpen, 2019)Traditional Chinese medicine (TCM) is one of the most established systems of medicine in the world. The therapeutic formulae used in TCM are frequently derived from aqueous decoctions of single plants or complex multicomponent ... -
Traditional Medicinal Knowledge documented in the Schools Manuscript Collection: An insight into the medical beliefs, practices and healing plants used in 1930s Ireland.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)The National Folklore Collection (NFC) in University College Dublin holds one of the largest collections of ethnographic material globally. In 2017, the Irish Folklore Commission Collection (1935-1970), housed within the ... -
Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (ASP+) in human respiratory epithelial cells
(2012)Organic cation/carnitine transporters (OCT/N) mediate uptake of positively charged molecules. Their role in lung epithelium, however, is not well understood. OCT/N expression and activity was studied in cell lines of human ...
