Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 421-440 of 559
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Primary Health Care and Community Pharmacy in Ireland: a lot of visions but little progress
(2020)Ireland is small country with a population of 4.8M which spent 6.9% of its gross domestic product on healthcare in 2018. Health services are provided through a twin track approach –all public services ... -
The production and characterisation of itraconazole multicomponent systems
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the poorly soluble triazole antifungal agent, itraconazole (ITZ). This compound was reported to form hydrochloride salts and cocrystals with a wide range of aliphatic dicarboxylic acids, which have ... -
Production and characterisation of spray dried particulate systems for pulmonary drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The work presented in this thesis concerns the application of a particle engineering technology, one-step spray drying method, to produce porous particles of antitubercular drugs, suitable for inhalation and to study the ... -
The production and characterization of fluoroquinolone amorphous solid dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Ciprofloxacin (CIP) is a Biopharmaceutics Classification System class 4 drug, which exhibits solid-state limited solubility. Among the different formulation options available to improve the solubility of such a compound, ... -
Production of cocrystals in an excipient matrix by spray drying
(2018-01)Spray drying is a well-established scale-up technique for the production of cocrystals. However, to the best of our knowledge, the effect of introducing a third component into the feed solution during the ... -
The production of crystalline powders by spray drying to improve the mechanical and flow properties of an active pharmaceutical ingredient
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The overall aim of this research was to crystallise a drug onto the surface of an excipient (EXP) using a spray dryer in order to improve the processability of the attached active pharmaceutical ingredient (API). The project ... -
The production, characterisation, stabilization and isolation of azole anti-fungal nanoparticles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredients (APIs): itraconazole (ITR), ketoconazole ... -
A Professional Body for Pharmacy?
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Profiling harmful medication errors in an acute Irish teaching hospital.
(2012)Background: Medication error reporting systems in hospitals are faced with the challenge of processing vast numbers of reports which identify a myriad of safety issues. With such large volumes of data and limited resources ... -
A prospective observational pilot study of adverse drug reactions contributing to hospitalisation in a cohort of middle-aged adults aged 45- 64 years.
(2020)Purpose: Determine the prevalence, severity and preventability of adverse drug reactions (ADRs), ADRs causing or contributing to hospitalisation (cADRs) and preventable ADRs (pADRs) in middle-aged patients aged 45-64 years ... -
Provision of clinical pharmacy services during the COVID-19 pandemic: experiences of pharmacists from 16 European countries
(2020)Background: The pharmacy profession has an important role in the frontline healthcare response to COVID-19 across all settings. Objective: This study sought to explore the views and experiences of clinical pharmacists in ... -
The PSD-95/nNOS Complex: New Drugs for Depression?
(2012)Drug treatment of major depressive disorder is currently limited to the use of agents which influence monoaminergic neuronal transmission including inhibitors of presynaptic transporters and monoamine oxidase. Typically ... -
Pulmonary delivered polymeric micelles - pharmacokinetic evaluation and biodistribution studies
(2014)Polymeric micelles represent interesting delivery systems for pulmonary sustained release. However, little is known about their in vivo release and translocation profile after delivery to the lungs. In the present study, ... -
Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications
(2021)Medicinal plants have been used for a very long time to improve human health; they are gaining increasing popularity globally as drugs, complementary and alternative medicines, food supplements, cosmetics and, more surprisingly, ...
