Browsing Pharmacy and Pharmaceutical Sciences by Title
Now showing items 280-299 of 580
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Investigations of a spray-drying method for producing nanoporous / nano-particulate microparticles (NPMPs) of proteins and protein-excipient composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The research, presented in this thesis, concerns the application of a spray-drying method to produce nanoporous/nano-particulate microparticles (NPMPs) of proteins, stabilising excipients and composites. The proposed method, ... -
Investigations of extracellular vesicles in triple-negative breast cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Breast cancer is the most commonly diagnosed cancer worldwide accounting for 11.7% of the newly diagnosed 19.3 million cases in 2020. In Ireland breast cancer accounted for 10.8% of cancer cases and 23.8% of female cancers. ... -
Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The studies in this thesis explored the solid state and inhalation properties of various systems produced by the spray drying technique. The work focused on the feasibility analysis of spray drying as a means of producing ... -
Investigatons of the potential of crystalline excipients to prevent the process-induced amorphisation of active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)The focus of this thesis was to evaluate the impact of mechanical activation (milling and dry mixing) and spray drying on the crystallinity of selected active pharmaceutical ingredients (APIs) and to explore the feasibility ... -
ISEV position paper: extracellular vesicle RNA analysis and bioinformatics.
(2013)Extracellular vesicles (EVs) are the collective term for the various vesicles that are released by cells into the extracellular space. Such vesicles include exosomes and microvesicles, which vary by their size and/or protein ... -
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
(2010)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer?s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
Isosteviol has beneficial effects on palmitate-induced cell dysfunction and gene expression.
(2012)BACKGROUND: Long-term exposure to high levels of fatty acids impairs insulin secretion and exaggerates glucagon secretion. The aim of this study was to explore if the antihyperglycemic agent, Isosteviol (ISV), is able ... -
A journey from ethnomedicine in rural Kenya to network pharmacology using a critical research approach
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Background: Traditional medicine (TM) is widely practiced globally, with inter-country figures on usage ranging from 30 to 90%. Research on TM is conducted for a multiplicity of reasons, among them health care and ... -
Kinetic and structural studies of novel isosorbide-based ligand binding to esterase enzymes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The main goal of the project described herein was to examine and rationalise the binding of a novel class of compound based on isosorbide to cholinesterase enzymes. The compounds of interest had been prepared within the ... -
Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The concept of delivering proteins and peptides to the systemic circulation via the lungs has been extensively investigated over the last 20 years. Main drivers for the approach are the lungs’ high surface area, presumed ... -
Manganese: a new contrast agent for lung imaging?
(2012)Lung parenchyma remains one of the most difficult tissues to be imaged by means of magnetic resonance imaging (MRI). Several MRI techniques are routinely used for lung imaging. However, manganese-enhancement MRI ...
